1. GPCR/G Protein
  2. Mas-related G-protein-coupled Receptor (MRGPR)
  3. MrgprX2 antagonist-5

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin.

For research use only. We do not sell to patients.

MrgprX2 antagonist-5 Chemical Structure

MrgprX2 antagonist-5 Chemical Structure

CAS No. : 2527815-74-1

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Description

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin[1].

IC50 & Target

MrgprX2[1]

In Vitro

MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

434.85

Formula

C19H13ClF2N4O2S

CAS No.
SMILES

O=S1(N=C(NCC2=NC=CC=C2F)NC3=C(C4=C(Cl)C=CC=C4)C=C(C=C31)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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MrgprX2 antagonist-5 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MrgprX2 antagonist-5
Cat. No.:
HY-145195
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