2. NF-κB Apoptosis Immunology/Inflammation
  3. TNF Receptor Interleukin Related NF-κB NO Synthase
  4. Anti-inflammatory agent 55

Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model.

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Anti-inflammatory agent 55 Chemical Structure

Anti-inflammatory agent 55 Chemical Structure

CAS No. : 2924156-51-2

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Anti-inflammatory agent 55 Related Antibodies

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Description

Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].

Molecular Weight

373.32

Formula

C17H15N3O7
CAS No.
SMILES

O=C(NCCN1C(OC2=CC(OC)=CC=C12)=O)/C=C/C3=CC=C([N+]([O-])=O)O3
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Purity & Documentation
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Anti-inflammatory agent 55 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 552924156-51-2TNF ReceptorInterleukin RelatedNF-κBNO SynthaseTumor Necrosis Factor ReceptorTNFRILNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSAnti-inflammatory activityiNOSTNF-αIL-6IL-1βRAW264.7 macrophagesmouse auricle edema modelInhibitorinhibitorinhibit

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