Anti-inflammatory agent 55
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model.
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- CAS. Nr.: 2924156-51-2
- Formel: C17H15N3O7
- Molecular Weight:373.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
0.8 μM
Compound: 9j
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Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
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[PMID: 37561816] |
| RAW264.7 | IC50 |
10.3 μM
Compound: 9j
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Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
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[PMID: 37561816] |
| RAW264.7 | IC50 |
10.9 μM
Compound: 9j
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Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
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[PMID: 37561816] |
| RAW264.7 | IC50 |
11.8 μM
Compound: 9j
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Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
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[PMID: 37561816] |
| RAW264.7 | IC50 |
38.8 μM
Compound: 9j
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Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
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[PMID: 37561816] |
Chemical Information
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CAS. Nr. 2924156-51-2
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Molecular Weight 373.32
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Formel C17H15N3O7
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SMILES
O=C(NCCN1C(OC2=CC(OC)=CC=C12)=O)/C=C/C3=CC=C([N+]([O-])=O)O3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Anti-inflammatory agent 55 Related Classifications
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