Anti-inflammatory agent 55
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model.
For research use only. We do not sell to patients.
- CAS No.: 2924156-51-2
- Formula: C17H15N3O7
- Molecular Weight:373.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
0.8 μM
Compound: 9j
|
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by griess reagent based assay
|
[PMID: 37561816] |
| RAW264.7 | IC50 |
10.3 μM
Compound: 9j
|
Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-6 production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
|
[PMID: 37561816] |
| RAW264.7 | IC50 |
10.9 μM
Compound: 9j
|
Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of TNF-alpha production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
|
[PMID: 37561816] |
| RAW264.7 | IC50 |
11.8 μM
Compound: 9j
|
Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
Inhibition of IL-1beta production in LPS-induced mouse RAW264.7 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
|
[PMID: 37561816] |
| RAW264.7 | IC50 |
38.8 μM
Compound: 9j
|
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay
|
[PMID: 37561816] |
Chemical Information
-
CAS No. 2924156-51-2
-
Molecular Weight 373.32
-
Formula C17H15N3O7
-
SMILES
O=C(NCCN1C(OC2=CC(OC)=CC=C12)=O)/C=C/C3=CC=C([N+]([O-])=O)O3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 55 Related Classifications
HY-155821 Related Classifications
Powered by Bioz