2924156-51-2
Chemical Structure
Anti-inflammatory agent 55
- CAS No.: 2924156-51-2
- Formula:C17H15N3O7
- Molecular Weight:373.32
InChIKey: IVMYOCZCDZOSDA-ZZXKWVIFSA-N
SMILES: O=C(NCCN1C(OC2=CC(OC)=CC=C12)=O)/C=C/C3=CC=C([N+]([O-])=O)O3
Biological Activity: Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
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Anti-inflammatory agent 55 | Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model. | |||||||||||||||||||||
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Keywords
