1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Difelikefalin

Difelikefalin (Synonyms: CR-845; FE-202845)

Cat. No.: HY-17609 Purity: 99.15%
Handling Instructions

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

For research use only. We do not sell to patients.

Difelikefalin Chemical Structure

Difelikefalin Chemical Structure

CAS No. : 1024828-77-0

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5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

IC50 & Target

kappa opioid receptor (KOR)[1]

In Vitro

Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].

Molecular Weight

679.85

Formula

C₃₆H₅₃N₇O₆

CAS No.

1024828-77-0

SMILES

O=C(C1(N)CCN(C([[email protected]@H](CCCCN)NC([[email protected]@H](CC(C)C)NC([[email protected]@H](CC2=CC=CC=C2)NC([[email protected]@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

DifelikefalinCR-845FE-202845CR845CR 845FE202845FE 202845Opioid Receptorperipherallyrestrictedanti-inflammatorymodulatingprurituschronickidneydiseaseInhibitorinhibitorinhibit

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Difelikefalin
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