2. GPCR/G Protein
    Neuronal Signaling
  3. Opioid Receptor
  4. Difelikefalin

Difelikefalin  (Synonyms: CR-845; FE-202845)

Cat. No.: HY-17609 Purity: 99.65%
COA Handling Instructions

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Difelikefalin Chemical Structure

Difelikefalin Chemical Structure

CAS No. : 1024828-77-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 568 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 568 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].

IC50 & Target

kappa opioid receptor (KOR)[1]
In Vitro

Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

679.85

Appearance

Solid

Formula

C36H53N7O6
CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (147.09 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (147.09 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4709 mL 7.3546 mL 14.7091 mL
5 mM 0.2942 mL 1.4709 mL 2.9418 mL
10 mM 0.1471 mL 0.7355 mL 1.4709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.68 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.65%

COA (248 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

Difelikefalin1024828-77-0CR-845 FE-202845CR845CR 845FE202845FE 202845FE-202845Opioid Receptorperipherallyrestrictedanti-inflammatorymodulatingprurituschronickidneydiseaseInhibitorinhibitorinhibit

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