1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Lirimilast

Lirimilast (Synonyms: BAY 19-8004)

Cat. No.: HY-19672
Handling Instructions

Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties.

For research use only. We do not sell to patients.

Lirimilast Chemical Structure

Lirimilast Chemical Structure

CAS No. : 329306-27-6

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10 mM * 1 mL in DMSO USD 546 In-stock
Estimated Time of Arrival: December 31
5 mg USD 560 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties[1][2].

IC50 & Target[2]

PDE4

42 nM (IC50)

In Vitro

In PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL[1].

In Vivo

Since Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation[2].

Molecular Weight

443.26

Formula

C₁₇H₁₂Cl₂N₂O₆S

CAS No.

329306-27-6

SMILES

O=C(N)NC1=C(C(C2=CC=C(Cl)C=C2Cl)=O)OC3=CC(OS(=O)(C)=O)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LirimilastBAY 19-8004Phosphodiesterase (PDE)Anti-inflammatoryasthmaCOPDPDE4orallyInhibitorinhibitorinhibit

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Lirimilast
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