329306-27-6
Chemical Structure
Lirimilast
Synonym(s): BAY 19-8004
- CAS No.: 329306-27-6
- Formula:C17H12Cl2N2O6S
- Molecular Weight:443.26
IUPAC Name: 2-(2,4-dichlorobenzoyl)-3-ureidobenzofuran-6-yl methanesulfonate
InChIKey: YPFLFUJKZDAXRA-UHFFFAOYSA-N
SMILES: O=C(N)NC1=C(C(C2=CC=C(Cl)C=C2Cl)=O)OC3=CC(OS(=O)(C)=O)=CC=C13
Biological Activity: Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties[1][2].
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Lirimilast | 98.69% | Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties. | ||||||||||||||||||||
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- [1]. Grootendorst DC, et al. Efficacy of the novel phosphodiesterase-4 inhibitor BAY 19-8004 on lung function and airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). Pulm Pharmacol Ther. 2003;16(6):341-7. [Content Brief]
- [2]. Peter Norman. PDE4 inhibitors: sustained patenting activity as leading drugs near the market. Exp. Opin. Ther. Patents (2000) 10(9):1415-1427.
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