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  6. (E)-Naringenin chalcone

(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell.

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(E)-Naringenin chalcone Chemical Structure

(E)-Naringenin chalcone Chemical Structure

CAS No. : 25515-46-2

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(E)-Naringenin chalcone Related Antibodies

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Description

(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell[1][2][4].

In Vitro

(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50 value of 68 μg/mL[1].
(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production[2].
(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells[2].
(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-Naringenin chalcone Related Antibodies

RT-PCR[2]

Cell Line: 3T3-L1 adipocytes
Concentration: 25-100 μM
Incubation Time: 8 days
Result: Increased adiponectin mRNA levels up to 8.0-fold in a dose-dependent manner.

Western Blot Analysis[4]

Cell Line: RAW 264 macrophages
Concentration: 0,25, 50, 100, 200 μM
Incubation Time: 24 h
Result: Suppressed the degradation of IκB-α.
In Vivo

(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice[1].
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse type I allergic model[1]
Dosage: 0.8 mg/kg
Administration: Oral administration
Result: Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.
Animal Model: Allergic airway inflammation induced in mice[3]
Dosage: 0.8 mg/kg
Administration: Oral administration, daily
Result: Decreased cell numbers of the infiltrating leukocyte and eosinophils.
Decreased Muc5ac and gob-5 expression in the lungs.
Molecular Weight

272.26

Formula

C15H12O5
CAS No.
SMILES

OC(C=C1)=CC=C1/C=C/C(C2=C(C=C(O)C=C2O)O)=O.[(E)]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-Naringenin chalcone25515-46-2OthersTomato skin extractmast cellanti-allergicinflammationantioxidantadiponectinadipocyteNIH-3T33T3-L1macrophageInhibitorinhibitorinhibit

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