Anti-allergic activity of naringenin chalcone from a tomato skin extract
- Biosci Biotechnol Biochem. 2004 Aug;68(8):1706-11. doi: 10.1271/bbb.68.1706.
- 1. Research & Development Division, Kikkoman Corporation, Noda, Chiba 278-0037, Japan. [email protected]
The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. The tomato skin extract exerted the strongest inhibition of histamine release. Chlorogenic acid, rutin and naringenin were identified in the 60% ethanol extract of tomato skin. However, the extract contained an unknown compound which strongly inhibited histamine release. This active compound in tomato skin was identified as naringenin chalcone (trans-2'4'6'4-tetrahydroxychalcone). Naringenin chalcone inhibited histamine release with an IC(50) value of 68 microg/ml. The anti-allergic activity of the tomato skin extract was next investigated by the in vivo mouse ear-swelling response. We found that naringenin chalcone showed the strongest inhibitory effect of the Polyphenols of the tomato skin extract. These results indicate that a tomato skin extract could inhibit allergic reactions.
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Cat. No.Product NameDescriptionTargetResearch Area
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target: OthersResearch Areas: Inflammation/Immunology