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  3. Disease Research Fields Plants Ketones, Aldehydes, Acids
  4. Liliaceae Cardiovascular Disease
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  6. Alliin

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Alliin Chemical Structure

Alliin Chemical Structure

CAS No. : 556-27-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 130 In-stock
Solution
10 mM * 1 mL in Water USD 130 In-stock
Solid
1 mg USD 56 In-stock
5 mg USD 119 In-stock
10 mg USD 202 In-stock
20 mg USD 343 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Alliin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities[1][2].

In Vitro

Alliin (0-160 μM, 2 h) reduces lipid accumulation and ameliorates the cAMP Levels in 1,3-DCP-induced HepG2 cells[1].
Alliin (0-160 μM, 23 h) inhibits the expression levels of proteins and genes (SREBP-1, FAS, SREBP-2 and HMGCR) involved in AMPK–SREBPs signaling pathway in HepG2 Cells[1].
Alliin (100 μM, 6 h) inhibits p38, JNK and ERK1/2 phosphorylation and blocks MAPKs-mediated NF-κB/AP-1/STAT-1 signal transducer to improve the inflammatory responses in LPS-stimulated RAW264.7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alliin Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 10-1280 μM
Incubation Time: 24 h
Result: Decreased the cell viability at concentrations from 320 μM to 1280 μM.
Did not have cell toxicity at concentrations from 0 μM to 160 μM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 0-160 μM
Incubation Time: 23 h
Result: Increased the expression of p-AMPK and decreased the protein expression of AMPK at concentrations of 80 μM and 160 μM.
Inhibited the protein expression of SREBP-1, FAS, SREBP-2 and HMGCR by 1,3-DCP-induced at concentrations of 80 μM and 160 μM.

Western Blot Analysis[2]

Cell Line: RAW264.7
Concentration: 100 μg/mL
Incubation Time: 6 h
Result: Inhibited the protein expression of iNOS, IL-1β, IL-6, and TNF-α, and the production of NO.
Suppressed the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNAs.
Blocked JNK/ERK1/2-mediated transcriptional activation of PPARγ.
In Vivo

Alliin (500 mg/kg, i.g., 10 days) ameliorates colon damage and spleen changes in DSS colitis mouse model through reduces pro-inflammatory cytokines (iNOS, TNF-α and IL-6) expression and inhibits the phosphorylation of ERK1/2, JNK, p38 and PPARγ[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS colitis mouse model[2]
Dosage: 500 mg/kg
Administration: i.g., 10 days
Result: Decrease hematochezia symptom and diarrhea symptom.
Improved weight loss.
Reduced colon injury and inflammatory cell infiltration, restored the structure of colon epithelial and crypt.
Reduced the expression of iNOS, TNF-α and IL-6 mRNAs.
Molecular Weight

177.22

Formula

C6H11NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C[S@](CC=C)=O)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1410.68 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6427 mL 28.2135 mL 56.4270 mL
5 mM 1.1285 mL 5.6427 mL 11.2854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (564.27 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.86%

COA (245 KB) HNMR (227 KB) LCMS (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6427 mL 28.2135 mL 56.4270 mL 141.0676 mL
5 mM 1.1285 mL 5.6427 mL 11.2854 mL 28.2135 mL
10 mM 0.5643 mL 2.8214 mL 5.6427 mL 14.1068 mL
15 mM 0.3762 mL 1.8809 mL 3.7618 mL 9.4045 mL
20 mM 0.2821 mL 1.4107 mL 2.8214 mL 7.0534 mL
25 mM 0.2257 mL 1.1285 mL 2.2571 mL 5.6427 mL
30 mM 0.1881 mL 0.9405 mL 1.8809 mL 4.7023 mL
40 mM 0.1411 mL 0.7053 mL 1.4107 mL 3.5267 mL
50 mM 0.1129 mL 0.5643 mL 1.1285 mL 2.8214 mL
60 mM 0.0940 mL 0.4702 mL 0.9405 mL 2.3511 mL
80 mM 0.0705 mL 0.3527 mL 0.7053 mL 1.7633 mL
100 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alliin556-27-4OthersHypoglycemicantioxidantanti-inflammatoryantitumororally activeHepG2 cellsRAW264.7Inhibitorinhibitorinhibit

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