Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
Based on 1 Customer Validation
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is a superantigen exotoxin produced by Staphylococcus aureus. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) binds to TCR and MHC II outside the antigen-presenting site, thereby inducing unconventional polyclonal lymphocyte activation, excessive cytokine production, rapid shock, multiple organ failure syndrome and even death. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) exacerbates mammary gland inflammation and further induces mastitis. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) is thermostable and can be transmitted to humans via food, causing toxic shock syndrome. Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can be used in studies related to toxic shock syndrome and staphylococcal food poisoning.
For research use only. We do not sell to patients.
- Purity : 98.61%
- CAS No.: 137593-46-5
- Formula: C98H171N33O35
- Molecular Weight:2371.61
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) binds to the regions outside the canonical antigen-binding pockets of MHC II and TCR in a non-competitive allosteric manner, non-specifically activates the total T cell population, overactivates the NF-κB signaling cascade, and releases large amounts of proinflammatory cytokines; this toxin exhibits only typical superantigen activity in all relevant in vitro functional assays[1][2].
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) can penetrate the vaginal mucosal barrier and initiate a local inflammatory cascade in vaginal epithelial cell models[1].
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) retains an intact protein structure after standard pasteurization, and exacerbates the inflammatory phenotype in a milk-fermented mammary epithelial cell culture system[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 137593-46-5
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Appearance Solid
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Molecular Weight 2371.61
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Formula C98H171N33O35
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Color White to off-white
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Sequence
Lys-Gly-Glu-Lys-Val-Asp-Leu-Asn-Thr-Lys-Arg-Thr-Lys-Lys-Ser-Gln-His-Thr-Ser-Glu-Gly
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Sequence Shortening
KGEKVDLNTKRTKKSQHTSEG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (42.17 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4217 mL | 2.1083 mL | 4.2165 mL | 10.5414 mL |
| 5 mM | 0.0843 mL | 0.4217 mL | 0.8433 mL | 2.1083 mL | |
| 10 mM | 0.0422 mL | 0.2108 mL | 0.4217 mL | 1.0541 mL | |
| 15 mM | 0.0281 mL | 0.1406 mL | 0.2811 mL | 0.7028 mL | |
| 20 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5271 mL | |
| 25 mM | 0.0169 mL | 0.0843 mL | 0.1687 mL | 0.4217 mL | |
| 30 mM | 0.0141 mL | 0.0703 mL | 0.1406 mL | 0.3514 mL | |
| 40 mM | 0.0105 mL | 0.0527 mL | 0.1054 mL | 0.2635 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) Related Classifications
HY-P4984 Related Classifications
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