3-Oxo-hop-22(29)-ene

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3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory.

For research use only. We do not sell to patients.

3-Oxo-hop-22(29)-ene Chemical Structure

CAS No. : 25615-11-6

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Description

In Vitro

3-Oxo-hop-22(29)-ene (compound 2) (50 μM; 24 hours) reduces the viability of T. cruzi by more than 20%, and has a moderate effecton on T. rangeli and L. mexicana^[1].
3-Oxo-hop-22(29)-ene (10, 100 μM; 48 hours) causes 1.51% and 7.39% inhibition activity to yeast α-glucosidase respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Saccharomyces cerevisiae (type 1) and mammalian yeast (type 2) α-glucosidases, T. cruzi, T. rangeli, L. mexicana
Concentration:	10 μM, 50 μM, 100 μM
Incubation Time:	24 hours, 48 hours
Result:	Reduced the viability of T. cruzi by more than 20%, and had a moderate effecton on T. rangeli and L. mexicana Inhibited Yeast α-glucosidase.

In Vivo

3-Oxo-hop-22(29)-ene (0.31 μmol/ear; application; once) decreases 17.50 % the inflammation of mouse ear edema model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male CD-1 mice (25-30 g) (Mouse ear edema model induced by 12-O-tetradecanoylphorbol acetate (TPA))^[1]
Dosage:	0.31 μmol/ear
Administration:	Apply to both faces of the right ear; once
Result:	Decreased 17.50% the inflammation of mouse ear edema model.

Molecular Weight

424.70

Formula

C₃₀H₄₈O

CAS No.

25615-11-6

SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CC[C@@H]4C(C)=C)C)C)([H])[C@@]5([C@@](C(C)(C(CC5)=O)C)([H])CC1)C

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Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. López-Huerta FA, et al. Hopane-type triterpenes from Cnidoscolus spinosus and their bioactivities. Bioorg Chem. 2020 Jul;100:103919. [Content Brief]

3-Oxo-hop-22(29)-ene Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Oxo-hop-22(29)-ene25615-11-6Glucosidaseanti-inflammationT. cruziT. rangeliL. mexicanaInhibitorinhibitorinhibit

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