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Camobucol  (Synonyms: AGIX 4207)

Cat. No.: HY-14916 Purity: 99.52%
COA Handling Instructions

Camobucol (AGIX 4207) is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

For research use only. We do not sell to patients.

Camobucol Chemical Structure

Camobucol Chemical Structure

CAS No. : 216167-92-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 607 In-stock
Solution
10 mM * 1 mL in DMSO USD 607 In-stock
Solid
5 mg USD 480 In-stock
10 mg USD 816 In-stock
20 mg USD 1440 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Camobucol (AGIX 4207) is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

In Vitro

Camobucol exhibits potent antioxidant activity toward lipid peroxides in vitro and displays enhanced cellular uptake. Camobucol selectively inhibits tumor necrosis factor (TNF)-α-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. In addition, Camobucol inhibits cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-α, IL-1β, and IL-6 from human peripheral blood mononuclear cells. Camobucol does not inhibit TNF-α-induced nuclear translocation of nuclear factor of the κ-enhancer in B cells (NF-κB), suggesting that the mechanism of action is independent of this redox-sensitive transcription factor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

574.88

Formula

C33H50O4S2

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OCC(O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7395 mL 8.6975 mL 17.3949 mL
5 mM 0.3479 mL 1.7395 mL 3.4790 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7395 mL 8.6975 mL 17.3949 mL 43.4873 mL
5 mM 0.3479 mL 1.7395 mL 3.4790 mL 8.6975 mL
10 mM 0.1739 mL 0.8697 mL 1.7395 mL 4.3487 mL
15 mM 0.1160 mL 0.5798 mL 1.1597 mL 2.8992 mL
20 mM 0.0870 mL 0.4349 mL 0.8697 mL 2.1744 mL
25 mM 0.0696 mL 0.3479 mL 0.6958 mL 1.7395 mL
30 mM 0.0580 mL 0.2899 mL 0.5798 mL 1.4496 mL
40 mM 0.0435 mL 0.2174 mL 0.4349 mL 1.0872 mL
50 mM 0.0348 mL 0.1739 mL 0.3479 mL 0.8697 mL
60 mM 0.0290 mL 0.1450 mL 0.2899 mL 0.7248 mL
80 mM 0.0217 mL 0.1087 mL 0.2174 mL 0.5436 mL
100 mM 0.0174 mL 0.0870 mL 0.1739 mL 0.4349 mL
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Camobucol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Camobucol
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