Diclofenac epolamine
Based on 1 Customer Validation
Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID). Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.95%
- CAS. Nr.: 119623-66-4
- Formel: C20H24Cl2N2O3
- Molecular Weight:411.32
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Flector Patch (Diclofenac epolamine) (1.3% w/w, 24 hours) increases diclofenac partitioning into the skin[1]. Flector Patch (Diclofenac epolamine) (1.3% w/w) loaded by Microemulsion (ME) enhances the transport of drug through skin and sustains to 12 h after removal of ME[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat paw edema inflammation model (induced with carrageenan)[2]
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Dosage:1.3% w/w
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Administration:Exteral application
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Result:Inhibited edema and showed anti-inflammatory efficacy at 6 hours after application.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 119623-66-4
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Appearance Solid
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Molecular Weight 411.32
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Formel C20H24Cl2N2O3
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Color Off-white to light yellow
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SMILES
OCCN1CCCC1.OC(CC(C=CC=C2)=C2NC3=C(C=CC=C3Cl)Cl)=O
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Synonyms
Diclofenac hydroxyethylpyrrolidine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (243.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Del Río-Sancho S, et al. Topical delivery of diclofenac into and across equine skin from a novel liquid diclofenac epolamine formulation. J Vet Pharmacol Ther. 2016 Dec. 39(6):578-583. [Content Brief]
[2]. Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 2013 Sep 10;453(2):569-78. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4312 mL | 12.1560 mL | 24.3120 mL | 60.7799 mL |
| 5 mM | 0.4862 mL | 2.4312 mL | 4.8624 mL | 12.1560 mL | |
| 10 mM | 0.2431 mL | 1.2156 mL | 2.4312 mL | 6.0780 mL | |
| 15 mM | 0.1621 mL | 0.8104 mL | 1.6208 mL | 4.0520 mL | |
| 20 mM | 0.1216 mL | 0.6078 mL | 1.2156 mL | 3.0390 mL | |
| 25 mM | 0.0972 mL | 0.4862 mL | 0.9725 mL | 2.4312 mL | |
| 30 mM | 0.0810 mL | 0.4052 mL | 0.8104 mL | 2.0260 mL | |
| 40 mM | 0.0608 mL | 0.3039 mL | 0.6078 mL | 1.5195 mL | |
| 50 mM | 0.0486 mL | 0.2431 mL | 0.4862 mL | 1.2156 mL | |
| 60 mM | 0.0405 mL | 0.2026 mL | 0.4052 mL | 1.0130 mL | |
| 80 mM | 0.0304 mL | 0.1519 mL | 0.3039 mL | 0.7597 mL | |
| 100 mM | 0.0243 mL | 0.1216 mL | 0.2431 mL | 0.6078 mL |
Diclofenac epolamine Related Classifications
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