Diclofenac epolamine  (Synonyms: Diclofenac hydroxyethylpyrrolidine)

Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID)^[1]. Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies^[2].

Flector Patch (Diclofenac epolamine) (1.3% w/w, 24 hours) increases diclofenac partitioning into the skin^[1].
Flector Patch (Diclofenac epolamine) (1.3% w/w) loaded by Microemulsion (ME) enhances the transport of drug through skin and sustains to 12 h after removal of ME^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flector Patch (Diclofenac epolamine) (1.3% w/w, exteral application) displays effective in treating inflammatory conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

411.32

C₂₀H₂₄Cl₂N₂O₃

119623-66-4

Solid

Off-white to light yellow

OCCN1CCCC1.OC(CC(C=CC=C2)=C2NC3=C(C=CC=C3Cl)Cl)=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Del Río-Sancho S, et al. Topical delivery of diclofenac into and across equine skin from a novel liquid diclofenac epolamine formulation. J Vet Pharmacol Ther. 2016 Dec. 39(6):578-583.  [Content Brief]

  [2]. Fouad SA, Basalious EB, El-Nabarawi MA, Tayel SA. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 2013 Sep 10;453(2):569-78.  [Content Brief]