1. Apoptosis
    Immunology/Inflammation
    MAPK/ERK Pathway
  2. TNF Receptor
    Interleukin Related
    p38 MAPK
  3. Semapimod tetrahydrochloride

Semapimod tetrahydrochloride (Synonyms: CNI-1493; CPSI-2364 tetrahydrochloride)

Cat. No.: HY-15509A Purity: >97.0%
Handling Instructions

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders.

For research use only. We do not sell to patients.

Semapimod tetrahydrochloride Chemical Structure

Semapimod tetrahydrochloride Chemical Structure

CAS No. : 164301-51-3

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Estimated Time of Arrival: December 31
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Description

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].

IC50 & Target

TNF-α

 

IL-1β

 

IL-6

 

p38 MAPK

 

In Vitro

Semapimod tetrahydrochloride leads to a significant decrease of p38-MAPK phosphorylation in macrophages, proinflammatory gene expression of macrophage inflammatory protein-1alpha, interleukin-6, monocyte chemoattractant protein-1, and intercellular adhesion molecule-1, and neutrophil infiltration. Semapimod tetrahydrochloride completely abrogated nitric oxide production within the tunica muscularis[2].
Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96. Semapimod tetrahydrochloride inhibits ATP-binding and ATPase activities of gp96 in vitro (IC50≈0.2-0.4 μM). Semapimod tetrahydrochloride desensitizes TLR signaling via its effect on the TLR chaperone gp96[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Semapimod tetrahydrochloride (5 mg/kg; i.p; daily for 2 weeks) ameliorates endothelial dysfunction in Obese Zucker (OZ) rats[1].
Semapimod tetrahydrochloride restores AM-induced akt phosphorylation and cGMP production in OZ rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male OZ rats[1]
Dosage: 5 mg/kg
Administration: I.p; daily for 2 weeks
Result: Restored endothelium-dependent vasorelaxation in OZ rats.
Clinical Trial
Molecular Weight

890.74

Formula

C₃₄H₅₆Cl₄N₁₈O₂

CAS No.

164301-51-3

SMILES

O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: >97.0%

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Keywords:

Semapimod tetrahydrochlorideCNI-1493CPSI-2364 tetrahydrochlorideCNI1493CNI 1493TNF ReceptorInterleukin Relatedp38 MAPKTumor Necrosis Factor ReceptorTNFRILproinflammatoryproductionnitricoxidemacrophagesinflammatoryautoimmuneendothelialdysfunctionInhibitorinhibitorinhibit

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Semapimod tetrahydrochloride
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