1. Anti-infection
    Apoptosis
  2. HIV
    Apoptosis
  3. Ro24-7429

Ro24-7429 

Cat. No.: HY-19149
Handling Instructions

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects.

For research use only. We do not sell to patients.

Ro24-7429 Chemical Structure

Ro24-7429 Chemical Structure

CAS No. : 139339-45-0

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Description

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

In Vitro

Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[1].
Ro 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation[1].
Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Peripheral blood mononuclear cells (PBMCs)
Concentration: 0.1 μM, 1 μM, 5 μM
Incubation Time: 3 days
Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs.
In Vivo

Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2]
Dosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg
Administration: i.p.; daily; for 14 or 21 days
Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.
Molecular Weight

272.73

Formula

C₁₄H₁₃ClN₄

CAS No.
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Ro24-7429
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HY-19149
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