139339-45-0
139339-45-0
Chemical Structure
Ro24-7429
- CAS. Nr.: 139339-45-0
- Formula:C14H13ClN4
- Molecular Weight:272.73
IUPAC Name: 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-benzo[e][1,4]diazepin-2-amine
InChIKey: LEAKQIXYSHIHCW-UHFFFAOYSA-N
SMILES: CNC1=NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1
Biological Activity: Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Ro24-7429 | 99.85% | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects. | ||||||||||||||||||||
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References
- [1]. A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. [Content Brief]
- [2]. Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. [Content Brief]
