1. Metabolic Enzyme/Protease
  2. Factor Xa
    Proteasome

Gabexate mesylate (Synonyms: FOY)

Cat. No.: HY-B0385 Purity: 98.51%
Handling Instructions

Gabexate Mesylate is a Factor X inhibitor.

For research use only. We do not sell to patients.

Gabexate mesylate Chemical Structure

Gabexate mesylate Chemical Structure

CAS No. : 56974-61-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 112 In-stock
Estimated Time of Arrival: December 31
10 mg USD 102 In-stock
Estimated Time of Arrival: December 31
100 mg USD 396 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

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  • References

Description

Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor . Target: Factor X Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase [1]. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppression of NFkappaB activation [2]. Gabexate mesylate inhibits competitively constitutive and inducible NO synthase (cNOS and iNOS, respectively), with Kivalues of 1.0×10?4M and 5.0×10?3M, respectively, at pH 7.4 and 37.0°C. gabexate mesylate increases iNOS mRNA expression in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ. Gabexate mesylate inhibits dose-dependently nitrite production (i.e. NO release) in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ [3].

Solvent & Solubility
In Vitro: 

H2O : ≥ 250 mg/mL (598.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3953 mL 11.9766 mL 23.9532 mL
5 mM 0.4791 mL 2.3953 mL 4.7906 mL
10 mM 0.2395 mL 1.1977 mL 2.3953 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

417.48

Formula

C₁₇H₂₇N₃O₇S

CAS No.

56974-61-9

SMILES

O=C(OCC)C1=CC=C(OC(CCCCCNC(N)=N)=O)C=C1.CS(=O)(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Gabexate mesylate
Cat. No.:
HY-B0385
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Gabexate mesylate

Cat. No.: HY-B0385