Cat. No.: HY-111588

Xanthoangelol

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 62949-76-2
Formula: C₂₅H₂₈O₄
Molecular Weight:392.49

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Xanthoangelol Chemical Structure

CAS No.: 62949-76-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

All AMPK Isoforms :

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	CC₅₀	11.8 μM Compound: 30	Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 36940609]
HEK293	IC₅₀	21.5 μM Compound: Xanthoangelol	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
HeLa	IC₅₀	1.03 μM Compound: 11	Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay	[PMID: 18841906]
HepG2	IC₅₀	13.7 μM Compound: Xanthoangelol	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
HUVEC	IC₅₀	>100 μM Compound: 1b	Toxicity against HUVEC incubated for 48 hrs by MTT assay Toxicity against HUVEC incubated for 48 hrs by MTT assay	[PMID: 25590864]
K562	IC₅₀	3.98 μM Compound: 1b	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 25590864]
MRC5	IC₅₀	21.7 μM Compound: Xanthoangelol	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
MRC5	IC₅₀	25 μM Compound: 23	Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis	[PMID: 28075580]
Raji	IC₅₀	273 molar ratio Compound: 1, xanthoangelol	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells Inhibition of TPA-induced EBV-early antigen activation in human Raji cells	[PMID: 16441065]
RAW264.7	IC₅₀	1.83 μM Compound: 11	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay	[PMID: 18841906]
THP-1	IC₅₀	23.6 μM Compound: Xanthoangelol	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
THP-1	IC₅₀	25 μM Compound: 23	Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis	[PMID: 28075580]

In Vitro

Xanthoangelol (1 and 5 μM, 24 h) combined with 4-HD suppresses proinflammatory factors, such as NO, TNF-a, and MCP-1 through inhibition of the JNK pathway in the co-culture system of fully differentiated 3T3-L1 adipocytes and RAW264.7 macrophages^[1].
Xanthoangelol (1-100 μM, 48 h) reduces the neuroblastoma and leukemia cells survival with cytotoxicity^[4].
Xanthoangelol (1-10 μM, 4 h) induces concentration-dependent early apoptosis followed by secondary cell death through activation of caspase-3 in Jurkat cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

LPS-stimulated RAW264.7 macrophages
Concentration:

1 and 5 μM
Incubation Time:

24 h
Result:

Decreased NO release, TNF-a and MCP-1 secretion, as well as the mRNA expression in LPS-stimulated RAW264.7 macrophages.

Western Blot Analysis^[1]

Cell Line:

LPS-stimulated RAW264.7 macrophages
Concentration:

5 μM
Incubation Time:

1 h
Result:

Alleviated JNK phosphorylation (by 38% and 49%, respectively), but had no effect on IjB degradation and p38 phosphorylation in LPS-stimulated RAW264.7 macrophages.

Cell Viability Assay^[4]

Cell Line:

IMR-32 and Jurkat cells
Concentration:

1-100 μM
Incubation Time:

48 h
Result:

Markedly reduced IMR-32 and Jurkat cells viability in a concentration-dependent manner.

Apoptosis Analysis^[4]

Cell Line:

Jurkat cells
Concentration:

1-10 μM
Incubation Time:

4 h
Result:

Significantly increased the ratio of apoptotic IMR-32 cells.

In Vivo

Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

High-fat diet-induced obese (DIO) mice^[1]
Dosage:

0.1% or 0.15% w/w
Administration:

mixed in a high-fat diet, daily for 14 weeks
Result:

Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.

Chemical Information

CAS No. 62949-76-2
Appearance Solid
Molecular Weight 392.49
Formula C₂₅H₂₈O₄
Color Light yellow to yellow
SMILES

O=C(/C=C/C1=CC=C(O)C=C1)C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)/C)=C2O
Structure Classification
- Flavonoids
- Chalcones
- Phenols
- Polyphenols
Initial Source
- Plants
- Umbelliferae
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Reprod Biomed Online

Xanthoangelol promotes early embryonic development of porcine embryos by relieving endoplasmic reticulum stress and enhancing mitochondrial function. [Abstract]

2023 Aug;47(2):103211. PMID: 37246104

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (254.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5478 mL

12.7392 mL

25.4784 mL

5 mM

0.5096 mL

2.5478 mL

5.0957 mL

10 mM

0.2548 mL

1.2739 mL

2.5478 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360. [Content Brief]

[2]. Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. [Content Brief]

[3]. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. [Content Brief]

[4]. Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5478 mL	12.7392 mL	25.4784 mL	63.6959 mL
	5 mM	0.5096 mL	2.5478 mL	5.0957 mL	12.7392 mL
	10 mM	0.2548 mL	1.2739 mL	2.5478 mL	6.3696 mL
	15 mM	0.1699 mL	0.8493 mL	1.6986 mL	4.2464 mL
	20 mM	0.1274 mL	0.6370 mL	1.2739 mL	3.1848 mL
	25 mM	0.1019 mL	0.5096 mL	1.0191 mL	2.5478 mL
	30 mM	0.0849 mL	0.4246 mL	0.8493 mL	2.1232 mL
	40 mM	0.0637 mL	0.3185 mL	0.6370 mL	1.5924 mL
	50 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2739 mL
	60 mM	0.0425 mL	0.2123 mL	0.4246 mL	1.0616 mL
	80 mM	0.0318 mL	0.1592 mL	0.3185 mL	0.7962 mL
	100 mM	0.0255 mL	0.1274 mL	0.2548 mL	0.6370 mL

Keywords

Xanthoangelol

1 Cited Publications

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Xanthoangelol

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Publications Citing Use of MedChemExpress (MCE) Xanthoangelol

All Monoamine Oxidase Isoforms

All AMPK Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Xanthoangelol Related Classifications

Cat. No.: HY-111588