1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. BCI hydrochloride

BCI hydrochloride (Synonyms: (E)-BCI hydrochloride)

Cat. No.: HY-115502A Purity: 99.78%
Handling Instructions

BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5.

For research use only. We do not sell to patients.

BCI hydrochloride Chemical Structure

BCI hydrochloride Chemical Structure

CAS No. : 95130-23-7

Size Price Stock Quantity
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BCI hydrochloride:

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Description

BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI hydrochloride specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI hydrochloride does not inhibit DUSP5[1].

IC50 & Target

DUSP6[1]

Molecular Weight

353.89

Formula

C₂₂H₂₄ClNO

CAS No.

95130-23-7

SMILES

O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4.Cl.[(E)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 15.62 mg/mL (44.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8257 mL 14.1287 mL 28.2574 mL
5 mM 0.5651 mL 2.8257 mL 5.6515 mL
10 mM 0.2826 mL 1.4129 mL 2.8257 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.56 mg/mL (4.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.56 mg/mL (4.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.56 mg/mL (4.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.78%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BCI(E)-BCIPhosphataseDUSP6anti-inflammatorycancerInhibitorinhibitorinhibit

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Product Name:
BCI hydrochloride
Cat. No.:
HY-115502A
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