95130-23-7
95130-23-7
Chemical Structure
BCI hydrochloride
Synonym(s): (E)-BCI hydrochloride
- CAS No.: 95130-23-7
- Formula:C22H24ClNO
- Molecular Weight:353.89
IUPAC Name: (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one hydrochloride
InChIKey: JPATUDRDKCLPTI-QMGGKDRNSA-N
SMILES: O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4.Cl
Biological Activity: BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BCI hydrochloride | 99.93% | BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research. | ||||||||||||||||||||
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References
- [1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45. [Content Brief]
- [2]. Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681. [Content Brief]
