1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
    NF-κB
  2. JAK
    STAT
    NF-κB
  3. Reticuline

Reticuline 

Cat. No.: HY-N1356 Purity: 98.11%
Handling Instructions

Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

For research use only. We do not sell to patients.

Reticuline Chemical Structure

Reticuline Chemical Structure

CAS No. : 485-19-8

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1 mg USD 343 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1029 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Reticuline, isolated from Litsea cubeba, shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. Reticuline exhibits cardiovascular effects[2].

IC50 & Target

JAK2

 

STAT3

 

NF-κB

 

In Vitro

Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC50=40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium[2].
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl2-induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca2+ channel blockade and/or 3) inhibition of Ca2+ release from norepinephrine-sensitive intracellular stores[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

329.39

Formula

C₁₉H₂₃NO₄

CAS No.

485-19-8

SMILES

OC1=CC2=C(C=C1OC)CCN(C)[[email protected]]2CC3=CC=C(OC)C(O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

ReticulineJAKSTATNF-κBJanus kinaseNuclear factor-κBNuclear factor-kappaBanti-inflammationalkaloidJAK2STAT3Inhibitorinhibitorinhibit

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Reticuline
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