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Cat. No.: HY-N1195

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Sugiol

(Synonyms: (+)-Sugiol; 10-Deoxoxanthoperol)

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Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 511-05-7
Formula: C₂₀H₂₈O₂
Molecular Weight:300.44

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sugiol Chemical Structure

CAS No.: 511-05-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

ERK1

ERK2

p38 MAPK

JNK1

JNK2

IL-1β

All p38 MAPK Isoforms :

All ERK Isoforms :

All JNK Isoforms :

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	<50 μg/mL Compound: 4	Inhibitory activity against human A549 lung tumor cell proliferation Inhibitory activity against human A549 lung tumor cell proliferation	[PMID: 15808460]
A549	GI₅₀	79.8 μM Compound: 13	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
A549	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BEAS-2B	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BXPC-3	GI₅₀	36.08 μM Compound: 13	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HCT-116	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human HCT116 colon tumor cell line Growth inhibitory activity against human HCT116 colon tumor cell line	[PMID: 15808460]
HL-60	GI₅₀	68.64 μM Compound: 13	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
K562	IC₅₀	6.7 μM Compound: Sugiol	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 30684866]
MCF7	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
MDA-MB-231	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human MDA-MB-231 breast tumor cell line Growth inhibitory activity against human MDA-MB-231 breast tumor cell line	[PMID: 15808460]
MIA PaCa-2	IC₅₀	17.9 μM Compound: 10	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MRC5	GI₅₀	>100 μM Compound: 13	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
NCI-H23	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human NCI-H23 lung tumor cell line Growth inhibitory activity against human NCI-H23 lung tumor cell line	[PMID: 15808460]
PANC-1	GI₅₀	87.94 μM Compound: 13	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	>100 μM Compound: 13	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
SMMC-7721	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
SW480	IC₅₀	>10 μM Compound: 17	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
SW-620	GI₅₀	<50 μg/mL Compound: 4	Growth inhibitory activity against human SW620 colon tumor cell line Growth inhibitory activity against human SW620 colon tumor cell line	[PMID: 15808460]
Vero	IC₅₀	24.6 μM Compound: 2	Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells	[PMID: 25462275]
Vero	IC₅₀	45.4 μM Compound: 2	Cytotoxicity against african green monkey Vero cells after 72 hrs Cytotoxicity against african green monkey Vero cells after 72 hrs	[PMID: 25462275]

In Vitro

Sugiol (5-30 μM; 30 min) inhibits TNF-α and proIL-1β/IL-1β protein production in J774A.1 cells^[1].
Sugiol (5-30 μM; 30 min) inhibits MAPK activation, suppresses ERK1/2, JUNK1/2, and p38 phosphorylation in LPS-induced J774A.1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

J774A.1 macrophages cells stimulated with LPS
Concentration:

5 μM, 10 μM, 20 μM, and 30 μM
Incubation Time:

30 min
Result:

Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.

Chemical Information

CAS No. 511-05-7
Appearance Solid
Molecular Weight 300.44
Formula C₂₀H₂₈O₂
Color White to off-white
SMILES

O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
Synonyms

(+)-Sugiol; 10-Deoxoxanthoperol
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71(4):300-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Sugiol

MCE Bioactive Compound Library

Natural Product Library Plus

All p38 MAPK Isoforms

All ERK Isoforms

All JNK Isoforms

All Interleukin Related Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sugiol

MCE Bioactive Compound Library

Natural Product Library Plus

All p38 MAPK Isoforms

All ERK Isoforms

All JNK Isoforms

All Interleukin Related Isoforms

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Sugiol Related Classifications

Cat. No.: HY-N1195