511-05-7
511-05-7
Chemical Structure
Sugiol
Synonym(s): (+)-Sugiol; 10-Deoxoxanthoperol
- CAS No.: 511-05-7
- Formula:C20H28O2
- Molecular Weight:300.44
IUPAC Name: (4aS,10aS)-6-hydroxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a,10,10a-hexahydrophenanthren-9(1H)-one
InChIKey: IPEHJNRNYPOFII-AZUAARDMSA-N
SMILES: O=C1C2=C(C=C(O)C(C(C)C)=C2)[C@@]3(C)CCCC(C)(C)[C@]3([H])C1
Biological Activity: Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Sugiol | 99.88% | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages. | ||||||||||||||||||||
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11-Hydroxysugiol | 11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D3 receptor (VDR). | |||||||||||||||||||||
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7-Oxodehydroabietinol | 7-Oxodehydroabietinol is a selective inhibitor targeting the human herpesvirus HHV-2. 7-Oxodehydroabietinol can be used in anti-herpesvirus drug development to target HHV-2 infection. | |||||||||||||||||||||
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Nimbiol | Nimbiol exhibits binding energy for FtsZ and shows potential anti-FtsZ effect. | |||||||||||||||||||||
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14-Hydroxydehydroabietane | 14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane induces ultrastructural changes in Leishmania braziliensis promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis. | |||||||||||||||||||||
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2-((1R,2R)-2-Formyl-1,3,3-trimethylcyclohexyl)-4-hydroxy-5-isopropylbenzaldehyde | 2-((1R,2R)-2-Formyl-1,3,3-trimethylcyclohexyl)-4-hydroxy-5-isopropylbenzaldehyde is a natural product. | |||||||||||||||||||||
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(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone | (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a Palmitate, can be isolated from the root tissue of Salvia miltiorrhiza. (3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3) shows anti-cancer activity against human cancer cell lines with DC50s of 25.5 μg/mL (HeLa), 37.5 μg/mL (HepG2), 30.2 μg/mL (OVCAR-3), respectively. | |||||||||||||||||||||
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(+)-Totarol | 98.46% | (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections. | ||||||||||||||||||||
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Hinokiol | Hinokiol is a natural diterpene. | |||||||||||||||||||||
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Ferruginol | 96.91% | Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities. | ||||||||||||||||||||
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12-Hydroxydehydroabietic acid | 12-Hydroxydehydroabietic acid is a diterpenoid found in the whole plant of Gaultheria yunnanensis. 12-Hydroxydehydroabietic acid weakly inhibits pro-inflammatory cytokine TNF-α production in LPS (HY-D1056)-induced macrophages. | |||||||||||||||||||||
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