2. Anti-infection
  3. Parasite
  4. 14-Hydroxydehydroabietane

14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of *Leishmania infantum* and *Leishmania braziliensis*. 14-Hydroxydehydroabietane induces ultrastructural changes in *Leishmania braziliensis* promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by *Leishmania infantum* and *Leishmania braziliensis*. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis.

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14-Hydroxydehydroabietane

14-Hydroxydehydroabietane Chemical Structure

CAS No. : 67119-95-3

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14-Hydroxydehydroabietane Related Antibodies

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Description

14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of *Leishmania infantum* and *Leishmania braziliensis*. 14-Hydroxydehydroabietane induces ultrastructural changes in *Leishmania braziliensis* promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by *Leishmania infantum* and *Leishmania braziliensis*. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis[1].

In Vitro

14-Hydroxydehydroabietane (Compound 5) (1-100 μM; 72 h) inhibits the growth of Leishmania infantum promastigotes and amastigotes, with IC50 values of 16.1 μM and 26.3 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania infantum and Leishmania braziliensis amastigotes in J774.2 macrophages, with IC50 values of 26.6 μM and 21.2 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania braziliensis promastigotes and amastigotes, with IC50 values of 20.7 μM and 18 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) exhibits low cytotoxicity against J774.2 macrophages, with an IC50 value of 467.4 μM[1].
14-Hydroxydehydroabietane (at IC25 concentration; 12 h) reduces the infection rates of Leishmania infantum and Leishmania braziliensis in J774.2 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

14-Hydroxydehydroabietane Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: J774.2 macrophage cells
Concentration: 1, 10, 25, 50 and 100 μM
Incubation Time: 72 h
Result: Exhibited low cytotoxicity to J774.2 macrophages with an IC50 of 467.4 μM.
Showed cytotoxicity 31-fold higher (less toxic) than the cytotoxicity IC50 of Glucantime.
Molecular Weight

286.45

Formula

C20H30O
CAS No.
SMILES

[H][C@]1(CCC2=C3O)C(C)(C)CCC[C@]1(C)C2=CC=C3C(C)C
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Storage

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References
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14-Hydroxydehydroabietane Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

14-Hydroxydehydroabietane67119-95-3ParasiteLeishmania infantumintracellular amastigoteLeishmania braziliensismacrophagespyruvateleishmaniasisJ774.2 macrophagesaxenic amastigoteglycosomal enzymepromastigoteInhibitorinhibitorinhibit

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