country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-185556

Copy Link Print Information

14-Hydroxydehydroabietane

14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane induces ultrastructural changes in Leishmania braziliensis promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 67119-95-3
分子式: C₂₀H₃₀O
分子量:286.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

14-Hydroxydehydroabietane 構造式

CAS 番号: 67119-95-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

14-Hydroxydehydroabietane (Compound 5) (1-100 μM; 72 h) inhibits the growth of Leishmania infantum promastigotes and amastigotes, with IC₅₀ values of 16.1 μM and 26.3 μM, respectively^[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania infantum and Leishmania braziliensis amastigotes in J774.2 macrophages, with IC₅₀ values of 26.6 μM and 21.2 μM, respectively^[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania braziliensis promastigotes and amastigotes, with IC50 values of 20.7 μM and 18 μM, respectively^[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) exhibits low cytotoxicity against J774.2 macrophages, with an IC₅₀ value of 467.4 μM^[1].
14-Hydroxydehydroabietane (at IC₂₅ concentration; 12 h) reduces the infection rates of Leishmania infantum and Leishmania braziliensis in J774.2 macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

J774.2 macrophage cells
Concentration:

1, 10, 25, 50 and 100 μM
Incubation Time:

72 h
Result:

Exhibited low cytotoxicity to J774.2 macrophages with an IC₅₀ of 467.4 μM.
Showed cytotoxicity 31-fold higher (less toxic) than the cytotoxicity IC₅₀ of Glucantime.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 67119-95-3
分子量 286.45
分子式 C₂₀H₃₀O
SMILES

[H][C@]1(CCC2=C3O)C(C)(C)CCC[C@]1(C)C2=CC=C3C(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ramírez-Macías I, et al. In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis. Mem Inst Oswaldo Cruz. 2012;107(3):370-376. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ