14-Hydroxydehydroabietane
14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane induces ultrastructural changes in Leishmania braziliensis promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis.
For research use only. We do not sell to patients.
- CAS No.: 67119-95-3
- Formula: C20H30O
- Molecular Weight:286.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
14-Hydroxydehydroabietane (Compound 5) (1-100 μM; 72 h) inhibits the growth of Leishmania infantum promastigotes and amastigotes, with IC50 values of 16.1 μM and 26.3 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania infantum and Leishmania braziliensis amastigotes in J774.2 macrophages, with IC50 values of 26.6 μM and 21.2 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) inhibits the growth of Leishmania braziliensis promastigotes and amastigotes, with IC50 values of 20.7 μM and 18 μM, respectively[1].
14-Hydroxydehydroabietane (1-100 μM; 72 h) exhibits low cytotoxicity against J774.2 macrophages, with an IC50 value of 467.4 μM[1].
14-Hydroxydehydroabietane (at IC25 concentration; 12 h) reduces the infection rates of Leishmania infantum and Leishmania braziliensis in J774.2 macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774.2 macrophage cells
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Concentration:1, 10, 25, 50 and 100 μM
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Incubation Time:72 h
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Result:Exhibited low cytotoxicity to J774.2 macrophages with an IC50 of 467.4 μM.
Showed cytotoxicity 31-fold higher (less toxic) than the cytotoxicity IC50 of Glucantime.
Chemical Information
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CAS No. 67119-95-3
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Molecular Weight 286.45
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Formula C20H30O
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SMILES
[H][C@]1(CCC2=C3O)C(C)(C)CCC[C@]1(C)C2=CC=C3C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
14-Hydroxydehydroabietane Related Classifications
HY-185556 Related Classifications
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