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Cat. No.: HY-107218

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11-Hydroxysugiol

11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D₃ receptor (VDR).

For research use only. We do not sell to patients.

CAS No.: 88664-08-8
Formula: C₂₀H₂₈O₃
Molecular Weight:316.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

11-Hydroxysugiol Chemical Structure

CAS No.: 88664-08-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D₃ receptor (VDR)^[1].

All RAR/RXR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	35.04 μM Compound: 12	Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
A549	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BEAS-2B	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
BXPC-3	GI₅₀	45.01 μM Compound: 12	Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HeLa	IC₅₀	39.6 μM Compound: 8	Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs Cytotoxicity against human HeLa cells in lag phase of growth after 48 hrs	[PMID: 24709561]
HeLa	IC₅₀	41.1 μM Compound: 8	Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs Cytotoxicity against human HeLa cells in log phase of growth after 48 hrs	[PMID: 24709561]
HEp-2	IC₅₀	46.2 μM Compound: 8	Cytotoxicity against human Hep2 cells in log phase of growth after 48 hrs Cytotoxicity against human Hep2 cells in log phase of growth after 48 hrs	[PMID: 24709561]
HEp-2	IC₅₀	49.4 μM Compound: 8	Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs Cytotoxicity against human Hep2 cells in lag phase of growth after 48 hrs	[PMID: 24709561]
HL-60	GI₅₀	35.26 μM Compound: 12	Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
HL-60	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
MCF7	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
MRC5	GI₅₀	40.19 μM Compound: 12	Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PANC-1	GI₅₀	43.14 μM Compound: 12	Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
PC-3	GI₅₀	41.03 μM Compound: 12	Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay	[PMID: 24210499]
RAW264.7	IC₅₀	15.5 μM Compound: 38	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess reagent based assay	[PMID: 29924604]
SMMC-7721	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
SW480	IC₅₀	>10 μM Compound: 16	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 33978415]
Vero	IC₅₀	47.5 μM Compound: 8	Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 hrs Cytotoxicity against African green monkey Vero cells in lag phase of growth after 48 hrs	[PMID: 24709561]
Vero	IC₅₀	47.5 μM Compound: 8	Cytotoxicity against African green monkey Vero cells in log phase of growth after 48 hrs Cytotoxicity against African green monkey Vero cells in log phase of growth after 48 hrs	[PMID: 24709561]

Chemical Information

CAS No. 88664-08-8
Molecular Weight 316.43
Formula C₂₀H₂₈O₃
SMILES

C[C@@]12C3=C(O)C(O)=C(C(C)C)C=C3C(C[C@@]1([H])C(C)(CCC2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meenaxi M. Maste, et al. Screening of Plectranthus amboinicus against COVID-19-in silico approach. J App Pharm Sci. 2020; 10(12): 90-97.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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