1. Anti-infection Apoptosis
  2. EBV HSV Apoptosis
  3. Ferruginol

Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities.

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Ferruginol Chemical Structure

Ferruginol Chemical Structure

CAS No. : 514-62-5

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Description

Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities[1][2][3].

In Vitro

Ferruginol (0-160 μM; 24 hours) exerts potent antiproliferative action against thyroid cancer cells, and an IC50 of 12 μM for the MDA-T32 cell line. The toxic effects of Ferruginol are less pronounced against normal cells[1].
Ferruginol (0-24 μM; 24 hours) induces apoptotic cell death of MDA-T32 cells. Ferruginol increases Bax expression and decreases Bcl-2 expression dose-dependently[1].
Ferruginol (0-24 μM; 24 hours) inhibits the MAPK and PI3K/AKT signaling pathway of MDA-T32 cells[1].
Ferruginol (0-24 μM; 24 hours) also causes ROS mediated alterations in the MMP of MDA-T32 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-T32 cells
Concentration: 0-160 μM
Incubation Time: 24 hours
Result: Exerted potent antiproliferative action against thyroid cancer cells.

Apoptosis Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Induced apoptotic cell death of MDA-T32 cells

Western Blot Analysis[1]

Cell Line: MDA-T32 cells
Concentration: 0 μM, 6 μM, 12 μM, and 24 μM
Incubation Time: 24 hours
Result: Blocked the MAPK and PI3K/AKT signaling pathway.
In Vivo

Ferruginol (20 mg/kg; p.o.; daily; for 4 weeks) exerts cardioprotection manifested as enhanced cardiac function and reduced structural damage and apoptosis. The transcriptome and other results revealed that Ferruginol facilitates PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation (MB and FAO) by increasing the expression of PGC-1α and concurrently promoting the expression of SIRT1-enhancing deacetylase SIRT1 deacetylating and activating PGC-1α[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20 g, 8-10 weeks old) with Doxorubicin (DOX)-induced cardiotoxicity (DIC)[3].
Dosage: 20 mg/kg
Administration: Administered intragastrically; daily; for 4 weeks
Result: Relieved Doxorubicin-induced cardiac structural and functional lesion.
Molecular Weight

286.45

Formula

C20H30O

CAS No.
SMILES

[H][C@]1(CCC2=C3)C(C)(C)CCC[C@]1(C)C2=CC(O)=C3C(C)C

Structure Classification
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Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Ferruginol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ferruginol
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