Diterpenoids from the twigs and leaves of Fokienia hodginsii

  • J Nat Prod. 2013 Jun 28;76(6):1032-8. doi: 10.1021/np400010c.
Xing-De Wu  1 ,  Juan He ,  Xing-Yao Li ,  Liao-Bin Dong ,  Xun Gong ,  Liu-Dong Song ,  Yan Li ,  Li-Yan Peng ,  Qin-Shi Zhao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 23691952 DOI: 10.1021/np400010c
Abstract

Five new isopimarane Diterpenoids, fokihodgins A-E (1-5), four new labdane Diterpenoids, fokihodgins F-I (6-9), and one new icetexane diterpenoid, fokihodgin J (10), as well as 18 known Diterpenoids were isolated from Fokienia hodginsii. The structures of the new compounds were determined on the basis of their spectroscopic analysis, and the absolute configurations of 1 and 6 were established by X-ray crystallographic analysis. Compound 9 showed moderate cytotoxicity against HL-60 and SMMC-7721 cell lines, with IC50 values of 9.10 and 7.50 μM, respectively.