Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens

  • Bioorg Med Chem Lett. 2005 Apr 15;15(8):2019-21. doi: 10.1016/j.bmcl.2005.02.057.
Kwang-Hee Son  1 ,  Hyun-Mi Oh ,  Sung-Kyu Choi ,  Dong Cho Han ,  Byoung-Mog Kwon
Affiliations
  • 1. Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 52 Uendong Yoosunggu Taejeon, 305-600 Republic of Korea.
PMID: 15808460 DOI: 10.1016/j.bmcl.2005.02.057
Abstract

A new abietane, namely, 20-hydroxyferruginol (1), together with known ferruginol (2), 18-hydroxyferruginol (3), sugiol (4), and 6alpha-hydroxysugiol (5), were isolated from the cones of Sequoia sempervirens. Their structures were elucidated through spectral data. Compounds 1 and 5 strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI(50) 2-5 microg/mL.