Diterpenoids from the feces of Trogopterus xanthipes

  • J Nat Prod. 2010 May 28;73(5):865-9. doi: 10.1021/np900814s.
Jun Zhao  1 ,  Hua-Jie Zhu ,  Xiao-Jiang Zhou ,  Tong-Hua Yang ,  Yuan-Yuan Wang ,  Jia Su ,  Yan Li ,  Yong-Xian Cheng
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20402524 DOI: 10.1021/np900814s
Abstract

Three new isopimarane Diterpenoids, trogopteroids A-C (1-3), four new aromatic Diterpenoids, trogopteroids D-G (4-7), and 12 known Diterpenoids were isolated from the feces of Trogopterus xanthipes. Their structures were identified using spectroscopic methods. The relative configuration of 1 was confirmed by quantum calculations. Compound 1 represents the first example of a norisopimarane diterpenoid with an 8alpha,15alpha-olide ring. With the exception of compound 14, all Diterpenoids were evaluated for cytotoxicity against seven human tumor cell lines.