12-Hydroxydehydroabietic acid
12-Hydroxydehydroabietic acid is a diterpenoid found in the whole plant of Gaultheria yunnanensis. 12-Hydroxydehydroabietic acid weakly inhibits pro-inflammatory cytokine TNF-α production in LPS (HY-D1056)-induced macrophages.
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- CAS. Nr.: 116032-84-9
- Formel: C20H28O3
- Molecular Weight:316.43
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Speicherung:
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774 | CC50 |
85.8 μM
Compound: 15
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Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 48 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 48 hrs by resazurin dye-based fluorometric analysis
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[PMID: 30840453] |
| LoVo | IC50 |
>25 μg/mL
Compound: 48
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Antiproliferative activity against human LoVo cells
Antiproliferative activity against human LoVo cells
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[PMID: 20022253] |
| QGY-7703 | IC50 |
>25 μg/mL
Compound: 48
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Antiproliferative activity against human QGY7703 cells
Antiproliferative activity against human QGY7703 cells
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[PMID: 20022253] |
| RAW264.7 | IC50 |
63 μg/mL
Compound: 48
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release
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[PMID: 20022253] |
In Vitro
12-Hydroxydehydroabietic acid (Compound 8) (50 μM; overnight) weakly inhibits LPS (HY-D1056)-induced TNF-α production in RAW 264.7 macrophages, with an inhibition ratio of 29.0% at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:RAW 264.7 macrophages
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Concentration:50 μM
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Incubation Time:overnight
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Result:Exhibited a 29.0% inhibition ratio against LPS-induced TNF-α production.
Chemical Information
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CAS. Nr. 116032-84-9
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Molecular Weight 316.43
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Formel C20H28O3
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SMILES
C[C@@]12C3=CC(O)=C(C(C)C)C=C3CC[C@@]1([H])[C@@](C)(CCC2)C(O)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
12-Hydroxydehydroabietic acid Related Classifications
HY-N9558 Related Classifications
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