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Cat. No.: HY-N9558

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12-Hydroxydehydroabietic acid

12-Hydroxydehydroabietic acid is a diterpenoid found in the whole plant of Gaultheria yunnanensis. 12-Hydroxydehydroabietic acid weakly inhibits pro-inflammatory cytokine TNF-α production in LPS (HY-D1056)-induced macrophages.

For research use only. We do not sell to patients.

CAS No.: 116032-84-9
Formula: C₂₀H₂₈O₃
Molecular Weight:316.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

12-Hydroxydehydroabietic acid Chemical Structure

CAS No.: 116032-84-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All TNF Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774	CC₅₀	85.8 μM Compound: 15	Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 48 hrs by resazurin dye-based fluorometric analysis Cytotoxicity against mouse J774 cells assessed as reduction in cell viability after 48 hrs by resazurin dye-based fluorometric analysis	[PMID: 30840453]
LoVo	IC₅₀	>25 μg/mL Compound: 48	Antiproliferative activity against human LoVo cells Antiproliferative activity against human LoVo cells	[PMID: 20022253]
QGY-7703	IC₅₀	>25 μg/mL Compound: 48	Antiproliferative activity against human QGY7703 cells Antiproliferative activity against human QGY7703 cells	[PMID: 20022253]
RAW264.7	IC₅₀	63 μg/mL Compound: 48	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release	[PMID: 20022253]

In Vitro

12-Hydroxydehydroabietic acid (Compound 8) (50 μM; overnight) weakly inhibits LPS (HY-D1056)-induced TNF-α production in RAW 264.7 macrophages, with an inhibition ratio of 29.0% at 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

RAW 264.7 macrophages
Concentration:

50 μM
Incubation Time:

overnight
Result:

Exhibited a 29.0% inhibition ratio against LPS-induced TNF-α production.

Chemical Information

CAS No. 116032-84-9
Molecular Weight 316.43
Formula C₂₀H₂₈O₃
SMILES

C[C@@]12C3=CC(O)=C(C(C)C)C=C3CC[C@@]1([H])[C@@](C)(CCC2)C(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao Y P, et al. Diterpenoids from Gaultheria yunnanensis[J]. Phytochemistry Letters, 2014, 8: 6-9.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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