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Tenosal 

Cat. No.: HY-12384
Handling Instructions

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

For research use only. We do not sell to patients.

Tenosal Chemical Structure

Tenosal Chemical Structure

CAS No. : 95232-68-1

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5 mg USD 450 Get quote
10 mg USD 850 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.

In Vivo

Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties. Extraction recovery measured is on average 95.75% for Tenosal, 98.71% for salicylic acid (SA) and 91.11% for TA. In the whole analysis of Tenosal extracted from plasma, the inter-assay coefficient of variation (C.V.) ranges from 1.00 to 5.86% and the intra assay C.V. is 5.01%. The administration of Tenosal allows a higher bioavailability of SA to be achieved than after dosing with ASA[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0282 mL 20.1410 mL 40.2820 mL
5 mM 0.8056 mL 4.0282 mL 8.0564 mL
10 mM 0.4028 mL 2.0141 mL 4.0282 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Both sexes of albino Sprague-Dawley rats (175 to 200 g body weight) are used for the experiment. Before the trial the animals are caged for seven days at 21 to 22°C and 55 to 75% relative humidity with a cycle of 12 h light-12 h dark. The animals are orally treated with Tenosal (300 mg/kg) or ASA (220 mg/kg) by a gastric gavage, both substances being suspended in 2% arabic gum. Six animals per group are killed at times 0 (baseline), 0.5, 1, 2, 4, 8, 16 and 24 h. Heparinized blood is sampled and centrifuged to obtain plasma. Liver, kidneys, lungs, myocardium, gastric wall and intestinal wall are also sampled from the animals killed 0, 1, 2, 4, 8 and 16 h after dosing. All the samples are stored in a freezer at -20°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

248.25

Formula

C₁₂H₈O₄S

CAS No.

95232-68-1

SMILES

O=C(C1=CC=CS1)OC2=CC=CC=C2C(O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tenosal
Cat. No.:
HY-12384
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Tenosal

Cat. No.: HY-12384