1. Apoptosis
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  3. Chrysosplenol D

Chrysosplenol D 

Cat. No.: HY-N6007
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Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities.

For research use only. We do not sell to patients.

Chrysosplenol D Chemical Structure

Chrysosplenol D Chemical Structure

CAS No. : 14965-20-9

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Description

Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4].

In Vitro

Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1].
Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2].
Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2].
Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2].
Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2].
Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4].
Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.31

Formula

C₁₈H₁₆O₈

CAS No.
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Chrysosplenol D
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