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  5. Fulvic Acid

Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes.

For research use only. We do not sell to patients.

Fulvic Acid

Fulvic Acid Chemical Structure

CAS No. : 479-66-3

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Based on 1 publication(s) in Google Scholar

Fulvic Acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fulvic Acid

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  • Customer Review

Description

Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes[1][2].

In Vitro

Fulvic acid (200 μg/mL) reduces TNF-α expression in LPS-exposed differentiated human U937 monocytes[1].
Fulvic acid reduces proinflammatory mediator release (B-hexosaminidase, histamine, TNF−α, IL-4, IL-13) from immunoglobulin-E-sensitized mast cells and basophil cells[1].
Fulvic acid increases oxidative stress in isolated cartilage cells from 12-day-old embryonic chicks[1].
Fulvic acid increases oxidative markers and induces apoptosis in hepatic cancer cell lines[1].
Fulvic acid (100 μg/mL) increases NO and ROS production and reduces cell viability in isolated murine peritoneal macrophages[1].
Fulvic acid increases copper absorption and reduces copper toxicity in porcine oviductal epithelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fulvic Acid Related Antibodies
In Vivo

Fulvic acid (topical) reduces dinitrofluorobenzene-induced ear swelling in Mus musculus to levels similar to steroid medication[1].
Fulvic acid (100 mg/kg; oral) reduces carrageenan-induced paw edema in rats to levels similar to nonsteroidal anti-inflammatory drugs[1].
Fulvic acid (300 mg/kg/day; daily; 4 weeks) reduces isoproterenol-induced myocardial oxidative damage in rats by decreasing lipid peroxidation and increasing antioxidant enzyme levels[1].
Fulvic acid (1.5% w/w in feed; daily; 60 days) modulates intestinal microbiota and increases digestive enzyme activity in juvenile loach[1].
Fulvic acid (211 p.p.m.; oral; continuously from parental generation through second generation) supplementation induces lysine overhydroxylation in bone and cartilage collagens, reduces collagen thermal stability, and decreases bone mechanical strength in Mus musculus[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified[1]
Dosage: 100 mg/kg
Administration: oral
Result: Reduced paw edema to levels similar to nonsteroidal anti-inflammatory drugs.
Animal Model: unspecified[1]
Dosage: 300 mg/kg/day
Administration: daily; 4 weeks
Result: Decreased lipid peroxidation and myocardial damage markers; significantly increased glutathione, superoxide dismutase, and catalase levels.
Animal Model: Paramisgurnus dabryanus (juvenile)[1]
Dosage: 1.5% (w/w in feed)
Administration: daily; 60 days
Result: Decreased abundance of Proteobacteria phyla and increased Firmicute levels in the intestine; increased abundance of Variovorax, Lactococcus, and Lactobacillus genera and decreased abundance of Serratia and Acinetobacter genera; increased activity of digestive enzymes (lysozyme, proteases, acid/alkaline phosphatases).
Animal Model: NMRI (50 days old at study start; second-generation studied at 49 days old)[2]
Dosage: 211 p.p.m.
Administration: oral (in drinking water; continuously from parental generation through second generation)
Result: Detected overhydroxylation of lysine residues in bone collagen I (Hyl/(Hyl + Lys) value of 0.434 ± 0.005 vs. 0.277 ± 0.005 in controls) and cartilage collagen II (Hyl/(Hyl + Lys) value of 0.552 vs. 0.482 in controls); Reduced melting temperature of bone collagen I by 1°C compared to controls; Lowered preload force at tibial breakage point (treated groups including FA had breakage forces of 2.75-5 N vs. 8.5-11.5 N in controls); Markedly affected reproduction, with no significant influence on growth.
Molecular Weight

308.24

Formula

C14H12O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C(C(COC(C)(O)C3)=C3OC2=CC(O)=C1O)=O)O
Structure Classification
Initial Source

microorganisms in soil
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Fulvic Acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fulvic Acid479-66-3Otherstumour necrosis factor alpha (TNF-α)interleukin-4 (IL-4)loach fishKashin-Beck diseaseporcine oviductal epithelial cellsmurine peritoneal macrophagescyclooxygenase 2 (COX2)primary human monocyteshepatic cancer cell linesprostaglandin E2 (PGE2)Inhibitorinhibitorinhibit

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