1. Protein Tyrosine Kinase/RTK
  2. ALK
    FAK

CEP-37440 

Cat. No.: HY-15841 Purity: 99.87%
Handling Instructions

CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).

For research use only. We do not sell to patients.

CEP-37440 Chemical Structure

CEP-37440 Chemical Structure

CAS No. : 1391712-60-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 114 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 756 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). IC50 value: 2.3 nM (FAK); 120 nM (ALK cellular IC50 in 75% human plasma) Target: Dual FAK/ALK Preparation of fused bicyclic 2,4-diaminopyrimidine derivatives as a dual ALK and FAK inhibitor By Jacobs, Martin J.; Ott, Gregory R. From PCT Int. Appl. (2013), WO 2013134353 A1 20130912.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (70.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7238 mL 8.6189 mL 17.2378 mL
5 mM 0.3448 mL 1.7238 mL 3.4476 mL
10 mM 0.1724 mL 0.8619 mL 1.7238 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

580.12

Formula

C₃₀H₃₈ClN₇O₃

CAS No.

1391712-60-9

SMILES

O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C4C(CCC[[email protected]](N5CCN(CCO)CC5)C4)=C3OC)=NC=C2Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CEP-37440
Cat. No.:
HY-15841
Quantity:

CEP-37440

Cat. No.: HY-15841