1. GPCR/G Protein
  2. Adenosine Receptor
  3. LUF6000

LUF6000 

Cat. No.: HY-13236 Purity: 99.57%
Handling Instructions

LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect.

For research use only. We do not sell to patients.

LUF6000 Chemical Structure

LUF6000 Chemical Structure

CAS No. : 890087-21-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 436 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 436 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 396 In-stock
Estimated Time of Arrival: December 31
10 mg USD 594 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2112 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE LUF6000

    LUF6000 purchased from MCE. Usage Cited in: Mediators Inflamm. 2014;2014:708746.

    LUF6000 down-regulates the A3AR and key inflammatory proteins. Protein analysis is performed using WB analysis. LUF6000 downregulates A3AR expression levels in the PBMCs of OA-induced rats (a). Jak-2 and STAT-1 are downregulated upon LUF6000 administration (b).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect[1][2].

    In Vitro

    Modulatory effect of 10 μM LUF6000 on Cl-IB-MECA-induced [35S]GTPγS binding in assays with HEK 293 cell membranes expressing human, dog, rabbit, or mouse A3 adenosine receptors with EC50 ranging from 39 to 172 nM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    LUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    411.33

    Formula

    C22H20Cl2N4

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 14.29 mg/mL (34.74 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4311 mL 12.1557 mL 24.3114 mL
    5 mM 0.4862 mL 2.4311 mL 4.8623 mL
    10 mM 0.2431 mL 1.2156 mL 2.4311 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1.43 mg/mL (3.48 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 1.43 mg/mL (3.48 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 1.43 mg/mL (3.48 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References
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    • Molarity Calculator

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    Product Name:
    LUF6000
    Cat. No.:
    HY-13236
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