1. GPCR/G Protein
  2. Adenosine Receptor
  3. LUF6000

LUF6000 

Cat. No.: HY-13236 Purity: 99.57%
Handling Instructions

LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).

For research use only. We do not sell to patients.

LUF6000 Chemical Structure

LUF6000 Chemical Structure

CAS No. : 890087-21-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 436 In-stock
Estimated Time of Arrival: December 31
5 mg USD 396 In-stock
Estimated Time of Arrival: December 31
10 mg USD 594 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2112 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE LUF6000

    LUF6000 purchased from MCE. Usage Cited in: Mediators Inflamm. 2014;2014:708746.

    LUF6000 down-regulates the A3AR and key inflammatory proteins. Protein analysis is performed using WB analysis. LUF6000 downregulates A3AR expression levels in the PBMCs of OA-induced rats (a). Jak-2 and STAT-1 are downregulated upon LUF6000 administration (b).
    • Biological Activity

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    Description

    LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). IC50 value: Target: A3 adenosine receptor LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists. LUF6000 exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher, and was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. Interestingly, LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist.

    Molecular Weight

    411.33

    Formula

    C₂₂H₂₀Cl₂N₄

    CAS No.

    890087-21-5

    SMILES

    ClC1=CC(NC2=NC3=C(C=CC=C3)C4=C2NC(C5CCCCC5)=N4)=CC=C1Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 14.29 mg/mL (34.74 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4311 mL 12.1557 mL 24.3114 mL
    5 mM 0.4862 mL 2.4311 mL 4.8623 mL
    10 mM 0.2431 mL 1.2156 mL 2.4311 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1.43 mg/mL (3.48 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 1.43 mg/mL (3.48 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 1.43 mg/mL (3.48 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    Keywords:

    LUF6000LUF 6000LUF-6000Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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    Product Name:
    LUF6000
    Cat. No.:
    HY-13236
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