1. MAPK/ERK Pathway
    Apoptosis
    Autophagy
  2. JNK
    Apoptosis
    Autophagy
  3. Juglanin

Juglanin 

Cat. No.: HY-N3442 Purity: ≥98.0%
Handling Instructions

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activity. Juglanin can induce apoptosis and autophagy on human breast cancer cells.

For research use only. We do not sell to patients.

Juglanin Chemical Structure

Juglanin Chemical Structure

CAS No. : 5041-67-8

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1 mg USD 500 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

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Description

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activity. Juglanin can induce apoptosis and autophagy on human breast cancer cells[1].

IC50 & Target[1]

JNK

 

Molecular Weight

418.35

Formula

C₂₀H₁₈O₁₀

CAS No.

5041-67-8

SMILES

O=C1C(O[[email protected]@H]2O[[email protected]@H](CO)[[email protected]](O)[[email protected]]2O)=C(C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References
Cell Assay
[1]

Breast cancer cells are planted in 96-well plates with a density of 5×103 cells/well. After 12 h, the cells are treated with different concentrations of Juglanin (0 to 40 μM) for different periods of time (24 h and 48 h). Then the fresh mixture of MTS and PMS is added and incubated for 4 h at 37°C according to the manufacturer's protocol. A microplate reader is conducted to determine the absorbance at 500 nm, and the IC50 values are assessed with the probit model. Each one is performed in triplicate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Male BALB/c-nude mice, aged 5 weeks, are used. They are maintained under specific pathogenfree conditions and supplied with sterilized food and water. On day 0, about 5×106 MCF-7 cells suspended in 0.1 mL PBS are inoculated subcutaneously in the right flank of each mouse (six mice each group). On day 9, when the tumors reach palpable size of around 200 mm3, mice are randomly assigned to three groups and receive daily intraperitoneal injection with 100 μL of vehicle (10% DMSO, 70% Cremophor/ethanol (3: 1), and 20% PBS), and 5 or 10 Juglanin mg/kg of celastrol. Tumor sizes are measured daily to observe dynamic changes in tumor growth. Body weights are also measured daily. After 7 days of drug administration, when the tumors of control group reach around 1600 mm3, all mice are killed. Tumors are dissected and stored in liquid nitrogen or fixed in formalin for further analysis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: ≥98.0%

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Keywords:

JuglaninJNKApoptosisAutophagyc-Jun N-terminal kinasebreast cancerROS/JNKG2/MphasearrestInhibitorinhibitorinhibit

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