Ligustrazine (Synonyms: Chuanxiongzine; Tetramethylpyrazine)

Name: Ligustrazine
Brand: MedChemExpress
SKU: HY-N0264
Rating: 5.0 (11 reviews)

Cat. No.: HY-N0264 Purity: 99.99%: Data Sheet
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Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong), is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats.

For research use only. We do not sell to patients.

CAS No. : 1124-11-4

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 11 publication(s) in Google Scholar

Other Forms of Ligustrazine:

Ligustrazine hydrochloride In-stock
Ligustrazine (Standard) Get quote

11 Publications Citing Use of MCE Ligustrazine

Histological Imaging/Staining

In Vivo Imaging

ELISA

In Vivo Efficacy Study

Cell Imaging/Staining

Cell Proliferation/Viability Assay

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jul 26:241:117193. [Abstract]; Ligustrazine (TMP, 25-100 mg/kg; i.p.; once daily for 7 days) can ameliorate liver injury in septic mice: Pathological changes in liver tissues of mice in each group, yellow arrows: hepatic cords; black arrows: hepatocytes. H&E staining results showed that in the Sham group, the liver tissues were structurally intact and morphologically normal, with no cell necrosis; in the CLP group, hepatocytes were swollen and necrotic, and hepatic cords were disorganized, accompanied by extensive inflammatory cell infiltration; compared with the CLP group, liver tissue damage in the CLP + XBJ, CLP + TMP L (25 mg/kg), CLP + TMP M (50 mg/kg), and CLP + TMP H (100 mg/kg) groups was significantly improved, hepatic cord structure was restored, and inflammatory cell infiltration was reduced, with the most significant improvement in the CLP + XBJ and CLP + TMP H groups.

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Jul 26:241:117193. [Abstract]; Effects of Ligustrazine (TMP, 25-100 mg/kg; i.p.; once daily for 7 days) on serum levels of IL-6, TNF-α, and IL-10 in septic mice.

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Sep 17:178180. [Abstract]; Representative M-mode echocardiograms. Echocardiographic analysis revealed that Ligustrazine (TMP, 60 mg/kg; i.p.; once daily for 10 days) treatment significantly improved 5-FU (20 mg/kg; i.p.; once daily for 10 days)-induced cardiac dysfunction in BALB/c mice.

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Sep 17:178180. [Abstract]; Morphological analysis showed that Ligustrazine (TMP, 60 mg/kg; i.p.; once daily for 10 days) attenuated 5-FU (20 mg/kg; i.p.; once daily for 10 days)-induced reductions in heart size, and significantly restored HW/TL ratio in BALB/c mice.

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Sep 17:178180. [Abstract]; Representative images of cardiac tissue with HE staining. Images were taken at 40 × and 400 ×. HE staining revealed that Ligustrazine (TMP, 60 mg/kg; i.p.; once daily for 10 days) significantly ameliorated 5-FU (20 mg/kg; i.p.; once daily for 10 days)-induced cardiomyocyte disarray, inflammatory cell infiltration, and histological disruptions in BALB/c mice.

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Sep 17:178180. [Abstract]; Representative micrographs were taken at 100 × magnification with a scale bar of 100 μm. Ligustrazine (TMP, 12.5 μM; 48 h) treatment significantly reversed the reduction in cell density induced by 5-FU (10 μM; 48 h).

: Ligustrazine purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Sep 17:178180. [Abstract]; Ligustrazine (TMP) (6.25-100 μM; 48 h) alone exhibited no cytotoxic effects on H9C2 cells. Co-treatment with TMP (12.5–50 μM; 48 h) significantly reversed the suppression of cell viability induced by 10 μM 5-FU.

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Description

Ligustrazine (Chuanxiongzine), an alkylpyrazine isolated from Ligusticum chuanxiong Hort. (Chuan Xiong)^[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Ligustrazine also has potential nootropic and anti-inflammatory activities in rats^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	15.22 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs in presence of piperlongumine by MTT assay Antiproliferative activity against human A549 cells after 72 hrs in presence of piperlongumine by MTT assay	[PMID: 29424539]
A549	IC₅₀	36.46 μM Compound: TMP	Antiproliferation activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
A549	IC₅₀	6.42 μM Compound: Lig	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay	[PMID: 37499289]
A549	IC₅₀	> 20 μM Compound: Lig	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37499289]
A549	IC₅₀	> 200 μM Compound: 1	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 26891099]
A549	IC₅₀	> 200 μM Compound: 1	Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometry Inhibition of thioredoxin reductase in human A549 cells by DTNB dye based microplate spectrophotometry	[PMID: 26891099]
A549/CDDP	IC₅₀	> 200 μM Compound: 1	Antiproliferative activity against human A549/CDDP cells after 72 hrs by MTT assay Antiproliferative activity against human A549/CDDP cells after 72 hrs by MTT assay	[PMID: 26891099]
A549/CDDP	IC₅₀	> 200 μM Compound: 1	Inhibition of thioredoxin reductase in human A549/CDDP cells by DTNB dye based microplate spectrophotometry Inhibition of thioredoxin reductase in human A549/CDDP cells by DTNB dye based microplate spectrophotometry	[PMID: 26891099]
Bel-7402	IC₅₀	> 20 μM Compound: Ligustrazine	Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 29432947]
EA.hy 926	EC₅₀	83.4 μM Compound: Ligustrazine, TMP	Cytoprotective activity against H2O2-induced cytotoxicity in human EAhy926 cells pre-incubated for 24 hrs before H2O2 challenge for 12 hrs by MTT assay Cytoprotective activity against H2O2-induced cytotoxicity in human EAhy926 cells pre-incubated for 24 hrs before H2O2 challenge for 12 hrs by MTT assay	10.1039/C4MD00022F
ECV-304	EC₅₀	0.6 mM Compound: TMP, Ligustrazine	Cytoprotective activity in H2O2-induced human ECV304 cells assessed as proliferation rate incubated for 24 hrs prior to H2O2-challenge measured after 12 hrs by MTT assay Cytoprotective activity in H2O2-induced human ECV304 cells assessed as proliferation rate incubated for 24 hrs prior to H2O2-challenge measured after 12 hrs by MTT assay	10.1039/C3MD20352B
ECV-304	EC₅₀	0.6 mM Compound: TMP, tetramethyl pyrazine	Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay	[PMID: 21993151]
ECV-304	EC₅₀	154.35 μM Compound: Lig, Ligustrazine	Protection against hydrogen peroxide-induced cell damage in human ECV304 cells treated 30 mins before hydrogen peroxide challenge measured after 6 hrs Protection against hydrogen peroxide-induced cell damage in human ECV304 cells treated 30 mins before hydrogen peroxide challenge measured after 6 hrs	[PMID: 19329327]
ECV-304	EC₅₀	452 μM Compound: ligustrazine	Protection of hydrogen peroxide-induced damage in ECV304 cells Protection of hydrogen peroxide-induced damage in ECV304 cells	[PMID: 17383884]
ECV-304	EC₅₀	549 μM Compound: Ligustrazine	Protection against H2O2-induced damage in human ECV304 cells preincubated for 24 hrs followed by H2O2 addition and measured after 12 hrs by MTT assay Protection against H2O2-induced damage in human ECV304 cells preincubated for 24 hrs followed by H2O2 addition and measured after 12 hrs by MTT assay	[PMID: 29432947]
HBMEC-2	EC₅₀	15.18 μM Compound: TMP	Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
HCT-116	IC₅₀	8.17 μM Compound: 2	Antiproliferative activity against human HCT116 cells after 72 hrs in presence of piperlongumine by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs in presence of piperlongumine by MTT assay	[PMID: 29424539]
HT-29	IC₅₀	> 20 μM Compound: Ligustrazine	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 29432947]
HUVEC	EC₅₀	600 μM Compound: Ligustrazine	Protection against H2O2-induced damage in HUVEC Protection against H2O2-induced damage in HUVEC	[PMID: 29432947]
HUVEC	EC₅₀	788 μM Compound: Ligustrazine	Protection against H2O2-induced damage in HUVEC preincubated for 0.5 hrs followed by H2O2 addition and measured after 12 hrs Protection against H2O2-induced damage in HUVEC preincubated for 0.5 hrs followed by H2O2 addition and measured after 12 hrs	[PMID: 29432947]
HeLa	IC₅₀	> 20 μM Compound: Ligustrazine	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 29432947]
HepG2	IC₅₀	38.25 μM Compound: TMP	Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
HepG2	IC₅₀	> 20 μM Compound: Ligustrazine	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 29432947]
K562	IC₅₀	5.09 μM Compound: 2	Antiproliferative activity against human K562 cells after 72 hrs in presence of piperlongumine by MTT assay Antiproliferative activity against human K562 cells after 72 hrs in presence of piperlongumine by MTT assay	[PMID: 29424539]
MCF7	IC₅₀	29.85 μM Compound: TMP	Antiproliferation activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
MCF7	IC₅₀	> 20 μM Compound: Ligustrazine	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29432947]
MDA-MB-231	IC₅₀	20.44 μM Compound: TMP	Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay	[PMID: 34186178]
MDA-MB-231	IC₅₀	4.86 μM Compound: Lig	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay	[PMID: 37499289]
MG-63	IC₅₀	10.3 μg/mL Compound: 46	Cytotoxicity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37300915]
NCI-H1975	IC₅₀	5.61 μM Compound: Lig	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay	[PMID: 37499289]
PC-12	EC₅₀	60 μM Compound: Ligustrazine	Neuroprotection against CoCl2-induced toxicity in rat PC12 cells Neuroprotection against CoCl2-induced toxicity in rat PC12 cells	[PMID: 29432947]
PC-12	EC₅₀	64.46 μM Compound: Ligustrazine	Neuroprotection against CoCl2-induced toxicity in rat PC12 cells preincubated for 36 hrs followed by CoCl2 addition measured after 12 hrs by MTT assay Neuroprotection against CoCl2-induced toxicity in rat PC12 cells preincubated for 36 hrs followed by CoCl2 addition measured after 12 hrs by MTT assay	[PMID: 29432947]
Platelet	IC₅₀	265.3 μM Compound: Ligustrazine, TMP	Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry	10.1039/C4MD00022F
SAOS-2	IC₅₀	24.7 μg/mL Compound: 46	Cytotoxicity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37300915]
SH-SY5Y	EC₅₀	17.59 μM Compound: TMP	Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay Neuroprotective activity against H2O2-induced cell damage in human SH-SY5Y cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay	[PMID: 31541868]
SK-HEP1	IC₅₀	9.67 μM Compound: Lig	Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay Antiproliferative activity against human SK-HEP1 cells assessed as inhibition of cell growth incubated for 48 hrs in presence of celastrol by MTT assay	[PMID: 37499289]
U-87MG ATCC	IC₅₀	16.15 μM Compound: 2	Antiproliferative activity against human U87MG cells after 72 hrs in presence of piperlongumine by MTT assay Antiproliferative activity against human U87MG cells after 72 hrs in presence of piperlongumine by MTT assay	[PMID: 29424539]
U2OS	IC₅₀	54.7 μg/mL Compound: 46	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37300915]

In Vitro

Ligustrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Ligustrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

136.19

Formula

C₈H₁₂N₂

CAS No.

1124-11-4

Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C)N=C(C)C(C)=N1

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (367.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.3427 mL	36.7134 mL	73.4268 mL
5 mM	1.4685 mL	7.3427 mL	14.6854 mL
10 mM	0.7343 mL	3.6713 mL	7.3427 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (18.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/0.5% Tween-80 in Saline water
Solubility: 15.92 mg/mL (116.90 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (277 KB) SDS (394 KB)

COA (251 KB) HNMR (126 KB) MS (301 KB) GC (176 KB)

Handling Instructions (2659 KB)

References

[1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638. [Content Brief]

[2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6. [Content Brief]

[3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.3427 mL	36.7134 mL	73.4268 mL	183.5671 mL
	5 mM	1.4685 mL	7.3427 mL	14.6854 mL	36.7134 mL
	10 mM	0.7343 mL	3.6713 mL	7.3427 mL	18.3567 mL
	15 mM	0.4895 mL	2.4476 mL	4.8951 mL	12.2378 mL
	20 mM	0.3671 mL	1.8357 mL	3.6713 mL	9.1784 mL
	25 mM	0.2937 mL	1.4685 mL	2.9371 mL	7.3427 mL
	30 mM	0.2448 mL	1.2238 mL	2.4476 mL	6.1189 mL
	40 mM	0.1836 mL	0.9178 mL	1.8357 mL	4.5892 mL
	50 mM	0.1469 mL	0.7343 mL	1.4685 mL	3.6713 mL
	60 mM	0.1224 mL	0.6119 mL	1.2238 mL	3.0595 mL
	80 mM	0.0918 mL	0.4589 mL	0.9178 mL	2.2946 mL
	100 mM	0.0734 mL	0.3671 mL	0.7343 mL	1.8357 mL

Ligustrazine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ligustrazine1124-11-4Chuanxiongzine TetramethylpyrazineApoptosisInhibitorinhibitorinhibit

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Ligustrazine (Synonyms: Chuanxiongzine; Tetramethylpyrazine)

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Other Forms of Ligustrazine:

Ligustrazine Related Antibodies

11 Publications Citing Use of MCE Ligustrazine

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•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

Ligustrazine Related Antibodies

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Complete Stock Solution Preparation Table

Ligustrazine Related Classifications

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