Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents

  • Bioorg Med Chem. 2009 Apr 15;17(8):3018-24. doi: 10.1016/j.bmc.2009.03.012.
Xian-Chao Cheng  1 ,  Xin-Yong Liu ,  Wen-Fang Xu ,  Xiu-Li Guo ,  Ning Zhang ,  Yu-Ning Song
Affiliations
  • 1. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China.
PMID: 19329327 DOI: 10.1016/j.bmc.2009.03.012
Abstract

A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound E1 was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed.