Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

  • Behav Brain Res. 2013 Sep 15;253:212-6. doi: 10.1016/j.bbr.2013.07.052.
Wei Wu  1 ,  Xiao Yu ,  Xiao-Ping Luo ,  Shu-Hua Yang ,  Dong Zheng
Affiliations
  • 1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China.
PMID: 23916742 DOI: 10.1016/j.bbr.2013.07.052
Abstract

Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.

Keywords
Memory; Scopolamine; Synapse; Tetramethylpyrazine.
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