Serratiopeptidase
Based on 1 Customer Validation
Serratiopeptidase (Brasan; Dasen) is an orally active zinc-containing metalloprotease belonging to the serralysin family. Serratiopeptidase reduces the release of inflammatory mediators such as prostaglandins, thromboxanes and interleukins by inhibiting COX, thereby relieving pain, swelling and redness. Serratiopeptidase exhibits antibiofilm, mucolytic and wound-healing activities. As a serine protease, Serratiopeptidase has the ability to dissolve blood clots, fibrin and atherosclerotic plaques. Serratiopeptidase degrades amyloid fibrils and has potential anti-Alzheimer's effects. Serratiopeptidase shows cytotoxicity against colon cancer cells.
For research use only. We do not sell to patients.
- CAS No.: 37312-62-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Serratiopeptidase exhibits in vitro cytotoxic activity against human colon adenocarcinoma Caco-2 cells[1].
Serratiopeptidase acts as an effective anti-biofilm agent against methicillin-resistant and susceptible Staphylococcus aureus, Staphylococcus epidermidis, and Listeria monocytogenes in vitro, modulates bacterial cell surface proteins to reduce adhesion, and exhibits no cytotoxic activity against mammalian cells[1].
Co-delivery of Serratiopeptidase with Curcumin (HY-N0005) via nanoparticles enhances in vitro anti-cancer activity against human cervical cancer HeLa cells and human breast cancer MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 37312-62-2
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Appearance Solid
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Color White to off-white
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SMILES
[Serratiopeptidase]
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Synonyms
Brasan; Dasen
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Nair SR, et al. Serratiopeptidase: An integrated View of Multifaceted Therapeutic Enzyme. Biomolecules. 2022;12(10):1468. Published 2022 Oct 13. [Content Brief]
[2]. Tiwari M, et al. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Serratiopeptidase Related Classifications
HY-E70127 Related Classifications
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- Serratiopeptidase
- 37312-62-2
- Brasan
- Dasen
- Ser/Thr Protease
- COX
- Bacterial
- Prostaglandin Receptor
- Interleukin Related
- cyclooxygenase (COX) I
- Listeria monocytogenes
- Staphylococcus epidermidis
- interleukin
- Serratia marcescens AD-W2
- Staphylococcus aureus
- prostaglandin
- COX II
- human colon adenocarcinoma Caco-2 cells
- arachidonic acid pathway
- Inhibitor
- inhibitor
- inhibit