1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. AZD-3161

AZD-3161 

Cat. No.: HY-117714
Handling Instructions

AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain.

For research use only. We do not sell to patients.

AZD-3161 Chemical Structure

AZD-3161 Chemical Structure

CAS No. : 1369501-46-1

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Description

AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain[1][2].

IC50 & Target

pIC50: 7.1 (NaV1.7 channel)[1]

In Vitro

AZD-3161 (compound 29) is selective for NaV1.7 over NaV1.5 and hERG, with pIC50s of 7.1, 4.9 and 4.9, respectively[1].
AZD-3161 inhibits Adenosine Transporter (AT) and Cannabinoid B1 (CB1) receptor, with IC50s of 1.8 μM and 5 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD-3161 (16-99 μmol/kg; p.o.) displays a dose dependent antinociceptive effect in the phase 1 of the formalin model of pain in rats[1].
AZD-3161 (3 μmol/kg; i.v.) exhibits long half-life (2.2 h) and Vss (4.2 L/kg)[1].
AZD-3161 (10 μmol/kg; p.o.) exhibits high oral bioavailability (44%), long half-life (4.8 h) and Cmax (0.30 μmol/L)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

474.43

Formula

C23H21F3N4O4

CAS No.
SMILES

O=C(C1=CC=C(COCC(F)(F)F)N=C1)N[[email protected]@H]2COC3=CC=CC(C4=NC=C(OC)N=C4)=C3C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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AZD-3161
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HY-117714
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