1369501-46-1
1369501-46-1
Chemical Structure
AZD-3161
- CAS No.: 1369501-46-1
- Formula:C23H21F3N4O4
- Molecular Weight:474.43
IUPAC Name: (S)-N-(5-(5-methoxypyrazin-2-yl)chroman-3-yl)-6-((2,2,2-trifluoroethoxy)methyl)nicotinamide
InChIKey: LRHQXIQLHVPUNA-INIZCTEOSA-N
SMILES: O=C(C1=CC=C(COCC(F)(F)F)N=C1)N[C@@H]2COC3=CC=CC(C4=NC=C(OC)N=C4)=C3C2
Biological Activity: AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain[1][2].
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AZD-3161 | AZD-3161 is a potent and selective blocker of NaV1.7 channel, with a pIC50 of 7.1. AZD-3161 can be used for the research of neuropathic and inflammatory pain. | |||||||||||||||||||||
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References
- [1]. Kers I, et, al. Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2012 Sep 1; 22(17): 5618-24. [Content Brief]
- [2]. Bagal SK, et, al. Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15; 24(16): 3690-9. [Content Brief]
Keywords
