1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. ARRY-382

ARRY-382 

Cat. No.: HY-136362 Purity: 99.89%
Handling Instructions

ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. ARRY-382 can be used for the research of advanced or metastatic cancers.

For research use only. We do not sell to patients.

ARRY-382 Chemical Structure

ARRY-382 Chemical Structure

CAS No. : 1313407-95-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 522 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. ARRY-382 can be used for the research of advanced or metastatic cancers[1].

IC50 & Target

IC50: 9 nM (CSF1R/c-Fms)[1]

In Vitro

ARRY-382 (1 µM) dramatically decreases the number of nurse-like cells (NLCs) compared to untreated cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

564.68

Formula

C₃₂H₃₆N₈O₂

CAS No.

1313407-95-2

SMILES

O=C(C1=CN=C2C=C(OCCN3CCN(C)CC3)C=CN21)NC4=CC=CC5=C4C(C6CC6)=NN5CC7=NC(C)=CC=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (14.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7709 mL 8.8546 mL 17.7091 mL
5 mM 0.3542 mL 1.7709 mL 3.5418 mL
10 mM 0.1771 mL 0.8855 mL 1.7709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ARRY-382ARRY382ARRY 382c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rtyrosinekinasesbone-relateddiseasescancerautoimmune disordersinflammatorycardiovascularpainInhibitorinhibitorinhibit

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Product Name:
ARRY-382
Cat. No.:
HY-136362
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