1. Cytoskeleton
    Immunology/Inflammation
  2. Integrin
    Complement System
  3. Leukadherin-1

Leukadherin-1 

Cat. No.: HY-15701 Purity: >98.0%
Handling Instructions

Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.

For research use only. We do not sell to patients.

Leukadherin-1 Chemical Structure

Leukadherin-1 Chemical Structure

CAS No. : 344897-95-6

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10 mM * 1 mL in DMSO USD 55 In-stock
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5 mg USD 50 In-stock
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10 mg USD 80 In-stock
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50 mg USD 290 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling[1][2][3].

In Vitro

Leukadherin-1 is a specific agonist of the leukocyte surface integrin CD11b/CD18 (αMβ2; CR3; Mac-1). Leukadherin‐1 pretreatment reduces secretion of interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1β by monokine‐stimulated NK cells. Leukadherin‐1 pretreatment also reduces secretion of IL‐1β, IL‐6 and TNF by Toll‐like receptor (TLR)‐2 and TLR‐7/8‐stimulated monocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Leukadherin-1 (1 mg/kg; i.p.; twice daily for 14 days) is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of bronchopulmonary dysplasia (BPD)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Newborn Sprague Dawley rat pups[1]
Dosage: 1 mg/kg
Administration: I.p.; twice daily for 14 days
Result: Beneficial on preventing the lung inflammatory response, improved alveolarization and vascular development, and reduced pulmonary vascular remodeling and PH in a hyperoxia-induced experimental model of BPD.
Molecular Weight

421.49

Formula

C₂₂H₁₅NO₄S₂

CAS No.

344897-95-6

SMILES

O=C(O)C1=CC=C(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3725 mL 11.8627 mL 23.7254 mL
5 mM 0.4745 mL 2.3725 mL 4.7451 mL
10 mM 0.2373 mL 1.1863 mL 2.3725 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

Leukadherin-1Leukadherin1Leukadherin 1IntegrinComplement SystemICAM-1inflammatoryvascularendotheliumleukocyteadhesionαMβ2CR3Mac-1Inhibitorinhibitorinhibit

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Product Name:
Leukadherin-1
Cat. No.:
HY-15701
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