2. Anti-infection
  3. Bacterial Antibiotic
  4. Nisin

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Nisin Chemical Structure

Nisin Chemical Structure

CAS No. : 1414-45-5

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Based on 1 publication(s) in Google Scholar

Nisin Related Antibodies

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  • Biological Activity

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Description

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3].

In Vitro

Nisin (100-800 μg/mL, 36 h) inhibits HNSCC cell ballooning[1].
Nisin (500-7000 IU/mL, 24 h) induces free-living amoeba acanthamoeba cell cycle arrest[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nisin Related Antibodies

Cell Viability Assay[2]

Cell Line: A. castellanii trophozoites
Concentration: 500, 1000, 2000, 3000, 4000, 6000, 7000 IU/mL
Incubation Time: 24, 72 h
Result: Inhibited amebic growth in a concentration-dependent manner at 24 h.

Cell Cycle Analysis[2]

Cell Line: A. castellanii trophozoites
Concentration: 7000 IU/mL
Incubation Time: 24 h
Result: Increased S phase to 13.3% and the percentage of G1 to 11.1%.
In Vivo

Nisin (25 mg/kg, intraperitoneally injected for 7 days) reduces uterine inflammation in rats by regulating the concentration of pro-inflammatory and anti-inflammatory cytokines[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat uterine endometritis model[3]
Dosage: 25 mg/kg
Administration: i.p. for 7 days
Result: Decreased the endometritis-induced increase in uterine weight, restored endometrial architecture.
Improved levels of B7-2, IFN-γ, IL-2 and IL-8.
Clinical Trial
Molecular Weight

3354.07

Formula

C143H230N42O37S7
CAS No.
Appearance

Solid

Color

Off-white to light brown

Sequence

Ile-{Abu}-{d-Cys}-Ile-Ala-Leu-Cys-{d-Abu}-Pro-Gly-Cys-Lys-{d-Abu}-Gly-Ala-Leu-Met-Gly-Cys-Asn-Met-Lys-{d-Abu}-Ala-{d-Abu}-Cys-His-Cys-Ser-Ile-His-Val-Ala-Lys (Disulfide bridge: Cys3-Cys7, Abu8-Cys11, Abu13-Cys19, Abu23-Cys26, Abu25-Cys28)
Sequence Shortening

I-{Abu}-{d-Cys}-IALC-{d-Abu}-PGCK-{d-Abu}-GALMGCNML-{d-Abu}-A-{d-Abu}-CHCSIHVAK (Disulfide bridge: Cys3-Cys7, Abu8-Cys11, Abu13-Cys19, Abu23-Cys26, Abu25-Cys28)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 6.67 mg/mL (1.99 mM; Need ultrasonic)

DMSO : 1 mg/mL (0.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2981 mL 1.4907 mL 2.9815 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

COA (232 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2981 mL 1.4907 mL 2.9815 mL 7.4536 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nisin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nisin1414-45-5BacterialAntibioticHNSCCRat uterine endometritisAnti-inflammatoryA. castellanii trophozoitesInhibitorinhibitorinhibit

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