2. Anti-infection
  3. Bacterial Antibiotic
  4. Nisin

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.

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CAS No. : 1414-45-5

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Based on 3 publication(s) in Google Scholar

Nisin Related Antibodies

Top Publications Citing Use of Products

    Nisin purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Jul 15:473:134536.

    Nisin (6-60 nM) greatly diminished growth and biosensor performance of L. lactis NZ9000.

    View All Antibiotic Isoform Specific Products:

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    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3].

    In Vitro

    Nisin (100-800 μg/mL, 36 h) inhibits HNSCC cell ballooning[1].
    Nisin (500-7000 IU/mL, 24 h) induces free-living amoeba acanthamoeba cell cycle arrest[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Nisin Related Antibodies

    Cell Viability Assay[2]

    Cell Line: A. castellanii trophozoites
    Concentration: 500, 1000, 2000, 3000, 4000, 6000, 7000 IU/mL
    Incubation Time: 24, 72 h
    Result: Inhibited amebic growth in a concentration-dependent manner at 24 h.

    Cell Cycle Analysis[2]

    Cell Line: A. castellanii trophozoites
    Concentration: 7000 IU/mL
    Incubation Time: 24 h
    Result: Increased S phase to 13.3% and the percentage of G1 to 11.1%.
    In Vivo

    Nisin (25 mg/kg, intraperitoneally injected for 7 days) reduces uterine inflammation in rats by regulating the concentration of pro-inflammatory and anti-inflammatory cytokines[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Rat uterine endometritis model[3]
    Dosage: 25 mg/kg
    Administration: i.p. for 7 days
    Result: Decreased the endometritis-induced increase in uterine weight, restored endometrial architecture.
    Improved levels of B7-2, IFN-γ, IL-2 and IL-8.
    Clinical Trial
    Molecular Weight

    3354.07

    Formula

    C143H230N42O37S7
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light brown

    Sequence

    Ile-Dhb-Ala-Ile-Dha-Leu-Ala-Abu-Pro-Gly-Ala-Lys-Abu-Gly-Ala-Leu-Met-Gly-Ala-Asn-Met-Lys-Abu-Ala-Aba-Ala-His-Ala-Ser-Ile-His-Val-Dha-Lys (Sulfide bridge: Ala3-Ala7, Abu8-Ala11, Abu13-Ala19, Abu23-Ala26, Aba25-Ala28)
    Sequence Shortening

    I-Dhb-AI-Dha-LA-Abu-PGAK-Abu-GALMGANMK-Abu-A-Aba-AHASIHV-Dha-K (Sulfide bridge: Ala3-Ala7, Abu8-Ala11, Abu13-Ala19, Abu23-Ala26, Aba25-Ala28)
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 6.67 mg/mL (1.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.2981 mL 1.4907 mL 2.9815 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    SDS (252 KB)

    COA (275 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.2981 mL 1.4907 mL 2.9815 mL 7.4536 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Nisin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nisin1414-45-5BacterialAntibioticHNSCCRat uterine endometritisAnti-inflammatoryA. castellanii trophozoitesInhibitorinhibitorinhibit

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