1. Epigenetics
    PI3K/Akt/mTOR
    JAK/STAT Signaling
    Stem Cell/Wnt
    Autophagy
  2. AMPK
    STAT
    Autophagy
  3. RSVA405

RSVA405 

Cat. No.: HY-103238
Handling Instructions

RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.

For research use only. We do not sell to patients.

RSVA405 Chemical Structure

RSVA405 Chemical Structure

CAS No. : 140405-36-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg USD 700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
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Description

RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity[1][2][3][4].

IC50 & Target[2]

AMPK

1 μM (EC50, in cell-based assays)

In Vitro

RSVA405 (0.2-2 μM; 24 h) inhibits adipocyte differentiation[2].
RSVA405 (0.2-2 μM; 24 h) significantly inhibits the expression of peroxisome proliferator-activated receptor (PPAR)-γ, fatty acid synthase (FAS) and fatty acid binding protein 4 (aP2) in 3T3-L1 cells[2].
RSVA405 (1-3 μM; 16 h) inhibits LPS-induced STAT3 activity, intracellular signaling, and cytokine response in activated RAW 264.7 macrophages[3].
RSVA405 (1-3 μM; 24 h) inhibits mTOR, induces autophagy, and facilitates the lysosomal degradation of Aβ, with an EC50 of ∼1 μM in APP-HEK293 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: 3T3-L1 preadipocytes
Concentration: 0.2, 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Increased the phosphorylation of AMPK and its substrate acetyl-CoA carboxylase (ACC).
Inhibited the accumulation of lipid droplets in a dose-dependent manner, with an IC50 of 0.5 μM.
In Vivo

RSVA405 (3 mg/kg; i.p.) attenuates renal injury and protects renal function after ischemia-reperfusion (I/R) in rats[1].
RSVA405 (20-100 mg/kg/d; p.o. for 11 weeks) significantly reduces the body weight gain of mice fed a high-fat diet[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (300-350 g) are induced I/R injury[1]
Dosage: 3 mg/kg
Administration: I.p. one hour before inducing I/R injury
Result: Decreased the levels of creatinine and blood urea nitrogen (BUN), by 35.8% and 44.3% in serum, respectively.
Decreased the levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) by 33.0% and 59.8% in serum, respectively.
Molecular Weight

312.37

Formula

C₁₇H₂₀N₄O₂

CAS No.

140405-36-3

SMILES

O=C(C1=CC=NC=C1)N/N=C/C2=CC=C(N(CC)CC)C=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (400.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2013 mL 16.0067 mL 32.0133 mL
5 mM 0.6403 mL 3.2013 mL 6.4027 mL
10 mM 0.3201 mL 1.6007 mL 3.2013 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

RSVA405RSVA 405RSVA-405AMPKSTATAutophagyAMP-activated protein kinaseAMP-ActivatedProteinKinaseanti-inflammatorySTAT3obesityAlzheimer'sdiseaseI/RInhibitorinhibitorinhibit

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RSVA405
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HY-103238
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