1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. Chicoric acid

Chicoric acid  (Synonyms: Cichoric acid; Dicaffeoyltartaric acid)

Cat. No.: HY-N0457 Purity: 99.95%
COA Handling Instructions

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.

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Chicoric acid Chemical Structure

Chicoric acid Chemical Structure

CAS No. : 6537-80-0

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Description

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3].

In Vitro

Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability[1].
Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway[1].
Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt[1].
Chicoric acid (25, 50, 100 µM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells[2].
Chicoric acid (100 µM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells[2].
Chicoric acid (100 µM) has no effects on HepG2 cell viability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 10-200 μM
Incubation Time: 24, 48, and 72 hours
Result: Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.

Apoptosis Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.

Western Blot Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Decreased the protein level of p-Akt in a dose- and time-dependent manner.
The protein level of total Akt was not affected
In Vivo

Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)[3]
Dosage: 60 mg/kg
Administration: Drinking water; daily; for 4 weeks
Result: Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion.
Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses.
Showed a remarkable increase in body weight starting at week 7.
Molecular Weight

474.37

Formula

C22H18O12

CAS No.
SMILES

O=C(O)[[email protected]](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[[email protected]@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C(O)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (210.81 mM; Need ultrasonic)

DMSO : 1 mg/mL (2.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL
10 mM 0.2108 mL 1.0540 mL 2.1081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (105.40 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

References
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