The total synthesis of fukiic acid, an HIV-1 integrase inhibitor

  • Eur J Med Chem. 2008 Oct;43(10):2268-71. doi: 10.1016/j.ejmech.2007.12.013.
Clémence Queffélec  1 ,  Fabrice Bailly ,  Gladys Mbemba ,  Jean-François Mouscadet ,  Zeger Debyser ,  Myriam Witvrouw ,  Philippe Cotelle
Affiliations
  • 1. Laboratoire de Chimie Organique et Macromoléculaire, CNRS UMR 8009, Université de Lille 1, 59655 Villeneuve d'Ascq, France.
PMID: 18243421 DOI: 10.1016/j.ejmech.2007.12.013
Abstract

A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any Antiviral activity in the MT-4 cells assay.