1. Metabolic Enzyme/Protease
    Anti-infection
  2. HIV Integrase
    HIV
  3. L-Chicoric Acid

L-Chicoric Acid (Synonyms: (-)-Chicoric acid; trans-Caffeoyltartaric acid)

Cat. No.: HY-N0457A Purity: 99.98% ee.: 99.60%
Handling Instructions

L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.

For research use only. We do not sell to patients.

L-Chicoric Acid Chemical Structure

L-Chicoric Acid Chemical Structure

CAS No. : 70831-56-0

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Based on 1 publication(s) in Google Scholar

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Description

L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].

IC50 & Target

IC50: ~100 nM (HIV-1 integrase)[1][2]
HIV-1[2]

In Vitro

L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells[1].
The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound[2].

Molecular Weight

474.37

Formula

C₂₂H₁₈O₁₂

CAS No.

70831-56-0

SMILES

O=C(O[[email protected]@H](C(O)=O)[[email protected]](C(O)=O)OC(/C=C/C1=CC=C(O)C(O)=C1)=O)/C=C/C2=CC=C(O)C(O)=C2.[Rotation(-)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1081 mL 10.5403 mL 21.0806 mL
5 mM 0.4216 mL 2.1081 mL 4.2161 mL
10 mM 0.2108 mL 1.0540 mL 2.1081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

L-Chicoric Acid(-)-Chicoric acidtrans-Caffeoyltartaric acidHIV IntegraseHIVHuman immunodeficiency virusNoncompetitivereversibleHIV-1dicaffeoyltartaricreplicationantiviralInhibitorinhibitorinhibit

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L-Chicoric Acid
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