1. Apoptosis
    Immunology/Inflammation
  2. TNF Receptor
    Interleukin Related
    COX
  3. 7,3',4'-Tri-O-methylluteolin

7,3',4'-Tri-O-methylluteolin (Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone)

Cat. No.: HY-N7012
Handling Instructions

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level.

For research use only. We do not sell to patients.

7,3',4'-Tri-O-methylluteolin Chemical Structure

7,3',4'-Tri-O-methylluteolin Chemical Structure

CAS No. : 29080-58-8

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Description

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid from the herb Lippia nodiflora L. (Verbenaceae) which has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. 7,3',4'-Tri-O-methylluteolin obviously reduces the prodn of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β in a concentration-dependent manner. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level[1].

IC50 & Target[1]

TNF-α

 

IL-6

 

IL-1β

 

COX-2

 

Molecular Weight

328.32

Formula

C₁₈H₁₆O₆

CAS No.

29080-58-8

SMILES

OC1=C2C(OC(C3=CC=C(OC)C(OC)=C3)=CC2=O)=CC(OC)=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

7,3',4'-Tri-O-methylluteolin5-Hydroxy-3',4',7-trimethoxyflavoneTNF ReceptorInterleukin RelatedCOXTumor Necrosis Factor ReceptorTNFRILCyclooxygenaseInhibitorinhibitorinhibit

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7,3',4'-Tri-O-methylluteolin
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HY-N7012
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